Diabetes, Metabolism and Endocrinology

Our focus is on finding the causes of metabolic and endocrine disease and capitalising on these discoveries to yield new treatments. We are world leaders in both large-scale genetic studies and global clinical trials, taking an international approach to advance our understanding and treatment of type 1 and type 2 diabetes. From target discovery for type 2 diabetes and probing the biochemistry of fat, through to understanding islet physiology and transplantation, investigating liver disease and unravelling the mechanisms behind rare endocrine tumours, our research truly spans the bed to bedside journey.

Around 70 minutes of active mouse pancreatic islet of Langerhans, visualised with two-photon microscope. The structure of the islet (red and yellow), as well as hormone secretory events (mostly insulin, green), have been outlined

Much of the work in this theme lies within the Oxford Centre for Diabetes, Endocrinology and Metabolism – a pioneering centre that combines basic and clinical research, clinical care and education. This is complemented by strong imaging expertise in the Oxford Centre for Clinical Magnetic Resonance Research.

We work closely with Novo Nordsik to coordinate a Fellowship Programme to train the next generation of leaders in diabetes research and the clinical translation of much of our work is supported by the NIHR Oxford Biomedical Research Centre’s Diabetes Theme, which we lead.