Our expertise is in clinical trials, whereby we aim to discover novel treatments for improving the health of patients with cardiac diseases. We use cardiovascular magnetic resonance imaging (CMR) and spectroscopy techniques to improve our understanding of myocardial metabolism and function, and for early detection of cardiac abnormalities in cardiomyopathy, heart failure, valve disease and diabetes. We use cardiopulmonary exercise test to understand cardiovascular exercise physiology, by studying how oxygen and other nutrients are used by the heart during exercise. We work closely with multidisciplinary research teams including MR physicists, biomedical engineers and other cardiac imaging experts in the UK and elsewhere in the world.
Our main current studies are
the tempest trial
This is a multicentre, randomised double-blind, placebo-controlled, phase 2 evaluation of the efficacy and mechanism of trientine in patients with hypertrophic cardiomyopathy (HCM). Initial studies have been promising in demonstrating a trend towards regression of left ventricular hypertrophy in patients taking trientine, which is second line therapy for Wilson’s disease. The Oxford group is in charge of the substudy evaluating the role of myocardial energetics in trientine potentially reversing the HCM phenotype. The results of this trial could make trientine the first therapy in HCM that alters its natural history. The trial is funded by the National Institute of Health Research (NIHR), sponsored by Manchester University NHS trust and co-ordinated by the Liverpool Clinical Trials Centre.
This is the largest multi-centre study investigating dilated cardiomyopathy (DCM), funded by the British Heart Foundation (BHF). DCM is a disease of the heart muscle affecting both adults and children. It can be acquired or inherited, and represents a frequent cause for heart failure, a syndrome where the heart fails to provide adequate amounts of oxygen for the body. DCM leads to a weakened, thinned heart muscle which can result in symptoms of breathlessness and heart rhythm abnormalities. To investigate this further, this study aims to improve understanding of the underlying genes causing DCM whilst identifying blood markers doctors can use to individualise treatment, and potentially to improve symptoms. This study seeks to recruit 1200 participants across several research centres in the UK.
THE IMPROVE-HCM TRIAL
This is a multi-centre, phase 2 clinical trial investigating a novel drug designed to target myocardial metabolism, with the aim to improve the efficiency of energy generation in patients with non-obstructive hypertrophic cardiomyopathy (HCM). Patients with symptomatic non-obstructive HCM represent one of the most important unmet needs for this genetic heart disease and this clinical trial aims to evaluate this novel drug therapy aimed at improving the lives of this subgroup of HCM patients. This study will measure the change from baseline of peak oxygen consumption as measured by cardiopulmonary exercise testing (CPET), and myocardial energy metabolism measured by magnetic resonance technique, in patients with non-obstructive HCM treated with this drug over a 12-week period. Safety and tolerability of the drug will also be examined. This trial is sponsored by Imbria Pharmaceuticals, Boston, USA.
The EMPA-Vision trial
- Dr Pablo Lamata, King’s College London, UK
- Dr Sanjay Prasad, Royal Brompton and Harefield NHS Trust, UK
- Prof Mary Sheppard, St George’s, University of London, UK
- Prof Jules Griffin, University of Cambridge, UK
- Prof Vicente Grau, University of Oxford, UK
collaborators (outside the UK)
- Prof Alistair Young, University of Auckland, New Zealand
- Dr James White, University of Calgary, Canada
- Dr Ntobeko Ntusi, Groote Schuur Hospital, Capetown, South Africa
- Dr Raymond Kwong, Havard Medical School, USA
- Prof Jean-Luc Balligand, Université catholique de Louvain, Belgium
- Dr Christopher Kramer, University of Virginia, USA