Fellows' Publications

Acute intermittent hypoxia drives hepatic de novo lipogenesis in humans and rodents.

Journal article

Hazlehurst JM. et al, (2022), Metabol Open, 14

The effects of endogenously- and exogenously-induced hyperketonemia on exercise performance and adaptation.

Journal article

Dearlove DJ. et al, (2022), Physiol Rep, 10

Assessing the effect of anesthetic gas mixtures on hyperpolarized 13 C pyruvate metabolism in the rat brain.

Journal article

Healicon R. et al, (2022), Magn Reson Med

Magnetic Resonance pH Imaging in Stroke – Combining the Old with the New

Journal article

LARKIN J. et al, (2022), Frontiers in Physiology

Concentration dependent effects of dichloroacetate in type-2 diabetic hearts assessed by hyperpolarized [1-13 C]-pyruvate MRI.

Journal article

Szocska Hansen ES. et al, (2021), NMR in biomedicine

Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid-base transporters and auto-regulate cardiomyocyte pH.

Journal article

Wilson AD. et al, (2021), Cardiovasc Res

Maternal iron deficiency perturbs embryonic cardiovascular development in mice

Journal article

Kalisch-Smith JI. et al, (2021), Nature Communications, 12

Energetic Basis for Exercise-Induced Pulmonary Congestion in Heart Failure With Preserved Ejection Fraction.

Journal article

Burrage MK. et al, (2021), Circulation

Tumour fatty acid metabolism in the context of therapy resistance and obesity.

Journal article

Hoy AJ. et al, (2021), Nat Rev Cancer

Diabetic mitochondria are resistant to palmitoyl CoA inhibition of respiration, which is detrimental during ischemia.

Journal article

Kerr M. et al, (2021), FASEB J, 35

Frequency drift in MR spectroscopy at 3T.

Journal article

Hui SCN. et al, (2021), Neuroimage, 241

Maternal iron deficiency perturbs embryonic cardiovascular development in mice.

Journal article

Kalisch-Smith JI. et al, (2021), Nat Commun, 12

Proof-of-Principle Demonstration of Direct Metabolic Imaging Following Myocardial Infarction Using Hyperpolarized 13C CMR.

Journal article

Apps A. et al, (2021), JACC Cardiovasc Imaging, 14, 1285 - 1288

Rapid, B 1 -insensitive, dual-band quasi-adiabatic saturation transfer with optimal control for complete quantification of myocardial ATP flux.

Journal article

Miller JJ. et al, (2021), Magn Reson Med, 85, 2978 - 2991

Association of Left Ventricular Global Longitudinal Strain With Cardiac Amyloid Load in Light Chain Amyloidosis

Journal article

Kim D. et al, (2021), JACC: Cardiovascular Imaging, 14, 1283 - 1285

C Impaired myocardial energetics as the basis for exercise-induced pulmonary congestion in heart failure with preserved ejection fraction

Conference paper

Burrage MK. et al, (2021), Young investigators award

A simple, open and extensible gating control unit for cardiac and respiratory synchronisation control in small animal MRI and demonstration of its robust performance in steady-state maintained CINE-MRI.

Journal article

Gilchrist S. et al, (2021), Magn Reson Imaging

Probing hepatic metabolism of [2-13C]dihydroxyacetone in vivo with 1H-decoupled hyperpolarized 13C-MR.

Journal article

Marco-Rius I. et al, (2021), MAGMA, 34, 49 - 56

A 3D hybrid-shot spiral sequence for hyperpolarized 13 C imaging.

Journal article

Tyler A. et al, (2021), Magn Reson Med, 85, 790 - 801

The diversity and breadth of cancer cell fatty acid metabolism.

Journal article

Nagarajan SR. et al, (2021), Cancer Metab, 9

HP acquisition methods: pulse sequences, reconstruction, and RF coils

Chapter

Gordon JW. and Miller JJ., (2021), Advances in Magnetic Resonance Technology and Applications, 49 - 74

Promoting high T2 contrast in Dy-doped MSNs through Curie effects

Journal article

Ellis CM. et al, (2021), Journal of Materials Chemistry B

Metabolic Effects of Doxorubicin on the Rat Liver Assessed With Hyperpolarized MRI and Metabolomics.

Journal article

Timm KN. et al, (2021), Front Physiol, 12

Continuous and non-invasive thermography of mouse skin accurately describes core body temperature patterns, but not absolute core temperature.

Journal article

van der Vinne V. et al, (2020), Sci Rep, 10

Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI.

Journal article

Timm KN. et al, (2020), Commun Biol, 3

Nicotinic acid receptor agonists impair myocardial contractility by energy starvation.

Journal article

Watson WD. et al, (2020), FASEB J, 34, 14878 - 14891

Effects of contrast agents on relaxation properties of 31P metabolites.

Journal article

Valkovič L. et al, (2020), Magn Reson Med

Rescue of myocardial energetic dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol.

Journal article

Kerr M. et al, (2020), JCI Insight, 5

Insulin signalling requires glucose to promote lipid anabolism in adipocytes

Journal article

Krycer JR. et al, (2020), Journal of Biological Chemistry, jbc.RA120.014907 - jbc.RA120.014907

Fatty acid oxidation is an adaptive survival pathway induced in prostate tumors by heat shock protein 90 inhibition.

Journal article

Nassar ZD. et al, (2020), Mol Cancer Res

Global sleep homeostasis reflects temporally and spatially integrated local cortical neuronal activity.

Journal article

Thomas CW. et al, (2020), Elife, 9

Modifying nutritional substrates induces macrovesicular lipid droplet accumulation and metabolic alterations in a cellular model of hepatic steatosis.

Journal article

Gunn PJ. et al, (2020), Physiol Rep, 8

Inpatient hypoglycaemia: understanding who is at risk.

Journal article

Ruan Y. et al, (2020), Diabetologia, 63, 1299 - 1304

Predicting the Risk of Inpatient Hypoglycemia With Machine Learning Using Electronic Health Records.

Journal article

Ruan Y. et al, (2020), Diabetes Care, 43, 1504 - 1511

Cardiac Energetics in Patients With Aortic Stenosis and Preserved Versus Reduced Ejection Fraction.

Journal article

Peterzan MA. et al, (2020), Circulation, 141, 1971 - 1985

Use of cardiac magnetic resonance to detect changes in metabolism in heart failure.

Journal article

Watson WD. et al, (2020), Cardiovasc Diagn Ther, 10, 583 - 597

Sleep and ageing: from human studies to rodent models.

Journal article

McKillop LE. and Vyazovskiy VV., (2020), Curr Opin Physiol, 15, 210 - 216

Hyperpolarized 13C MRI: A novel approach for probing cerebral metabolism in health and neurological disease.

Journal article

Grist JT. et al, (2020), J Cereb Blood Flow Metab, 40, 1137 - 1147

Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet.

Journal article

Kellard JA. et al, (2020), Mol Metab, 40

Noninvasive In Vivo Assessment of Cardiac Metabolism in the Healthy and Diabetic Human Heart Using Hyperpolarized 13C MRI.

Journal article

Rider OJ. et al, (2020), Circ Res, 126, 725 - 736

PYY, a Therapeutic Option for Type 2 Diabetes?

Journal article

Guida C. and Ramracheya R., (2020), Clinical Medicine Insights: Endocrinology and Diabetes, 13

Somatostatin secretion by Na+-dependent Ca2+-induced Ca2+ release in pancreatic delta-cells.

Journal article

Vergari E. et al, (2020), Nat Metab, 2, 32 - 40

Conditionally immortalized brown preadipocytes can switch between proliferative and differentiated states.

Journal article

Liu J. et al, (2019), Biochim Biophys Acta Mol Cell Biol Lipids, 1864

A role for placental kisspeptin in β cell adaptation to pregnancy

Journal article

Bowe JE. et al, (2019), JCI Insight, 4

Sleep homeostasis reflects temporally integrated local cortical neuronal activity

Journal article

Thomas CW. et al, (2019)

Sleep homeostasis during daytime food entrainment in mice

Journal article

Northeast R. et al, (2019), SLEEP

Water gated contrast switching with polymer-silica hybrid nanoparticles.

Journal article

Pellico J. et al, (2019), Chem Commun (Camb), 55, 8540 - 8543

The effect of metformin on hepatic fatty acid partitioning; an investigation using human in vivo and in vitro models

Conference paper

Green C. et al, (2019), JOURNAL OF HEPATOLOGY, 70, E794 - E795

SGLT2 inhibition does not reduce hepatic steatosis in overweight, insulin resistant patients without type 2 diabetes

Conference paper

Marjot T. et al, (2019), JOURNAL OF HEPATOLOGY, 70, E68 - E68

Importance of inpatient hypoglycaemia: impact, prediction and prevention.

Journal article

Ruan Y. et al, (2019), Diabet Med, 36, 434 - 443

PYY plays a key role in the resolution of diabetes following bariatric surgery in humans.

Journal article

Guida C. et al, (2019), EBioMedicine, 40, 67 - 76

Mapping tissue water T1 in the liver using the MOLLI T1 method in the presence of fat, iron and B0 inhomogeneity.

Journal article

Mozes FE. et al, (2019), NMR Biomed, 32

A multidisciplinary approach to the management of NAFLD is associated with improvement in markers of liver and cardio-metabolic health

Journal article

Moolla A. et al, (2019), Frontline Gastroenterology

Large expert-curated database for benchmarking document similarity detection in biomedical literature search.

Journal article

Brown P. et al, (2019), Database (Oxford), 2019

Sleep- and Wake-Like States in Small Networks In Vivo and In Vitro.

Journal article

McKillop LE. and Vyazovskiy VV., (2018), Handb Exp Pharmacol

Liver biochemical abnormalities in Turner syndrome: A comprehensive characterization of an adult population.

Journal article

Calanchini M. et al, (2018), Clin Endocrinol (Oxf), 89, 667 - 676

Hyperpolarized [1,4-13C2]Fumarate Enables Magnetic Resonance-Based Imaging of Myocardial Necrosis.

Journal article

Miller JJ. et al, (2018), JACC Cardiovasc Imaging, 11, 1594 - 1606

13C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI.

Journal article

Miller JJ. et al, (2018), Sci Rep, 8

Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS.

Journal article

Timm KN. et al, (2018), NMR Biomed, 31

Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders.

Journal article

Ang G. et al, (2018), Transl Psychiatry, 8

Cortical region-specific sleep homeostasis in mice: effects of time of day and waking experience.

Journal article

Guillaumin MCC. et al, (2018), Sleep, 41

CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets.

Journal article

Briant LJB. et al, (2018), Cell Rep, 23, 3300 - 3311

Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells.

Journal article

Hamilton A. et al, (2018), Diabetes, 67, 1128 - 1139

Cardiac applications of hyperpolarised magnetic resonance.

Journal article

Timm KN. et al, (2018), Prog Nucl Magn Reson Spectrosc, 106-107, 66 - 87

Hyperpolarized ketone body metabolism in the rat heart.

Journal article

Miller JJ. et al, (2018), NMR Biomed, 31

Effects of Aging on Cortical Neural Dynamics and Local Sleep Homeostasis in Mice.

Journal article

McKillop LE. et al, (2018), J Neurosci, 38, 3911 - 3928

Noninvasive Immunometabolic Cardiac Inflammation Imaging Using Hyperpolarized Magnetic Resonance.

Journal article

Lewis AJM. et al, (2018), Circ Res, 122, 1084 - 1093

Susceptibility-induced distortion correction in hyperpolarized echo planar imaging.

Journal article

Miller JJ. et al, (2018), Magn Reson Med, 79, 2135 - 2141

Bolusing frequency and amount impacts glucose control during hybrid closed-loop

Journal article

Bally L. et al, (2018), Diabetic Medicine, 35, 347 - 351

Sitagliptin and Roux-en-Y gastric bypass modulate insulin secretion via regulation of intra-islet PYY.

Journal article

Guida C. et al, (2018), Diabetes Obes Metab, 20, 571 - 581

Protocols and Methodologies in Basic Science and Clinical Cardiac MRI

Book

(2018)

Prevalence and severity of non-alcoholic fatty liver disease are underestimated in clinical practice: impact of a dedicated screening approach at a large university teaching hospital.

Journal article

Marjot T. et al, (2018), Diabet Med, 35, 89 - 98

THE CORTICAL NEURAL ACTIVITY OF MICE IS RESILIENT TO AGEING, DESPITE MARKED DISRUPTION IN GLOBAL SLEEP

Conference paper

McKillop LE. et al, (2017), SLEEP MEDICINE, 40, E218 - E219

Weighted averaging in spectroscopic studies improves statistical power.

Journal article

Miller JJ. et al, (2017), Magn Reson Med, 78, 2082 - 2094

Myocyte metabolic imaging with hyperpolarised MRI

Chapter

Miller JJ., (2017), Protocols and Methodologies in Basic Science and Clinical Cardiac MRI, 111 - 173

Faster insulin action is associated with improved glycaemic outcomes during closed-loop insulin delivery and sensor-augmented pump therapy in adults with type 1 diabetes

Journal article

Ruan Y. et al, (2017), Diabetes, Obesity and Metabolism, 19, 1485 - 1489

Lorcaserin improves glycemic control via a melanocortin neurocircuit

Journal article

Burke LK. et al, (2017), Molecular Metabolism, 6, 1092 - 1102

Cover Image, Volume 19, Issue 10

Journal article

Ruan Y. et al, (2017), Diabetes, Obesity and Metabolism, 19, i - i

The Role of PYY in Pancreatic Islet Physiology and Surgical Control of Diabetes.

Journal article

Guida C. et al, (2017), Trends Endocrinol Metab, 28, 626 - 636

Modeling Day-to-Day Variability of Glucose–Insulin Regulation Over 12-Week Home Use of Closed-Loop Insulin Delivery

Journal article

Ruan Y. et al, (2017), IEEE Transactions on Biomedical Engineering, 64, 1412 - 1419

HYPERPOLARIZED MAGNETIC RESONANCE IMAGING OF CARDIAC INFLAMMATION AND REPAIR

Conference paper

Lewis AJM. et al, (2017), HEART, 103, A151 - A151

The role of PYY in pancreatic islet physiology and surgical control of diabetes

Journal article

Guida C. et al, (2017), Trends in Endocrinology and Metabolism

Sensor Life and Overnight Closed Loop: A Randomized Clinical Trial

Journal article

Tauschmann M. et al, (2017), Journal of Diabetes Science and Technology, 11, 513 - 521

Mapping of intracellular pH in the in vivo rodent heart using hyperpolarized [1-13C]pyruvate.

Journal article

Lau AZ. et al, (2017), Magn Reson Med, 77, 1810 - 1817

Insulin and diet-induced changes in the ubiquitin-modified proteome of rat liver

Journal article

Nagarajan SR. et al, (2017), PLOS ONE, 12, e0174431 - e0174431

Hyperpolarised MRI of cardiac inflammation and repair

Poster

Lewis A. et al, (2017), LANCET, 389, 62 - 62

Closed-loop insulin delivery in inpatients with type 2 diabetes: a randomised, parallel-group trial

Journal article

Thabit H. et al, (2017), The Lancet Diabetes & Endocrinology, 5, 117 - 124

On the Metabolism of Exogenous Ketones in Humans.

Journal article

Stubbs BJ. et al, (2017), Front Physiol, 8

Simultaneous assessment of cardiac metabolism and perfusion using copolarized [1-13 C]pyruvate and 13 C-urea.

Journal article

Lau AZ. et al, (2017), Magn Reson Med, 77, 151 - 158

Simultaneous in vivo assessment of cardiac and hepatic metabolism in the diabetic rat using hyperpolarized MRS.

Journal article

Le Page LM. et al, (2016), NMR Biomed, 29, 1759 - 1767

Assessment of Metformin-Induced Changes in Cardiac and Hepatic Redox State Using Hyperpolarized[1-13C]Pyruvate.

Journal article

Lewis AJM. et al, (2016), Diabetes, 65, 3544 - 3551

GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states.

Journal article

Veprik A. et al, (2016), FASEB J, 30, 3860 - 3869

Stereotypic wheel running decreases cortical activity in mice.

Journal article

Fisher SP. et al, (2016), Nat Commun, 7

Dynamics of cortical network activity in non-rapid eye movement sleep in early and late adulthood mice

Conference paper

McKillop LE. et al, (2016), JOURNAL OF SLEEP RESEARCH, 25, 98 - 98

Serum metabolomics profiles in response to n-3 fatty acids in Chinese patients with type 2 diabetes: a double-blind randomised controlled trial

Journal article

Zheng J-S. et al, (2016), Scientific Reports, 6

Fast Padé Transform Accelerated CSI for Hyperpolarized MRS.

Journal article

Hansen ESS. et al, (2016), Tomography, 2, 117 - 124

Variability of Insulin Requirements Over 12 Weeks of Closed-Loop Insulin Delivery in Adults With Type 1 Diabetes

Journal article

Ruan Y. et al, (2016), Diabetes Care, 39, 830 - 832

Robust and high resolution hyperpolarized metabolic imaging of the rat heart at 7 T with 3D spectral-spatial EPI.

Journal article

Miller JJ. et al, (2016), Magn Reson Med, 75, 1515 - 1524

Cardiac perfusion imaging using hyperpolarized (13)C urea using flow sensitizing gradients.

Journal article

Lau AZ. et al, (2016), Magn Reson Med, 75, 1474 - 1483

Imaging Bone-Cartilage Interactions in Osteoarthritis Using [18F]-NaF PET-MRI.

Journal article

Savic D. et al, (2016), Mol Imaging, 15, 1 - 12

Fellows' Publications

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