Fellows' Publications
Latest publications
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Developing a metabolic clearance rate framework as a translational analysis approach for hyperpolarized 13C magnetic resonance imaging.
Journal article
Grist JT. et al, (2023), Sci Rep, 13
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Reversible pH-responsive MRI contrast with paramagnetic polymer micelles.
Journal article
Ellis CM. et al, (2023), Chem Commun (Camb)
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Cardiometabolic risk factors vary with age differently in females and males
Journal article
Miller JJ. and Heather LC., (2022), Nature Cardiovascular Research
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Direct observation of the molecular mechanism underlying protein polymerization.
Journal article
Hundt N. et al, (2022), Sci Adv, 8
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Assessing the effect of anesthetic gas mixtures on hyperpolarized 13 C pyruvate metabolism in the rat brain.
Journal article
Healicon R. et al, (2022), Magn Reson Med, 88, 1324 - 1332
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Functional and Metabolic Imaging in Heart Failure with Preserved Ejection Fraction: Promises, Challenges, and Clinical Utility.
Journal article
Burrage MK. et al, (2022), Cardiovasc Drugs Ther
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A neuroimmunometabolic view on the cephalic phase of insulin release.
Journal article
Sarker G. and Domingos AI., (2022), Cell Metab, 34, 940 - 942
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Glycogen-autophagy: Molecular machinery and cellular mechanisms of glycophagy.
Journal article
Koutsifeli P. et al, (2022), J Biol Chem, 298
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Concentration-dependent effects of dichloroacetate in type 2 diabetic hearts assessed by hyperpolarized [1-13 C]-pyruvate magnetic resonance imaging.
Journal article
Hansen ESS. et al, (2022), NMR Biomed, 35
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Acute intermittent hypoxia drives hepatic de novo lipogenesis in humans and rodents.
Journal article
Hazlehurst JM. et al, (2022), Metabol Open, 14
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The effects of endogenously- and exogenously-induced hyperketonemia on exercise performance and adaptation.
Journal article
Dearlove DJ. et al, (2022), Physiol Rep, 10
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Promoting high T2 contrast in Dy-doped MSNs through Curie effects.
Journal article
Ellis CM. et al, (2022), J Mater Chem B, 10, 302 - 305
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A phase 2a trial investigating ninerafaxstat - a novel cardiac mitotrope for the treatment of diabetic cardiomyopathy (IMPROVE-DiCE)
Conference paper
Hundertmark M. et al, (2022), EUROPEAN HEART JOURNAL, 43, 246 - 246
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Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid-base transporters and auto-regulate cardiomyocyte pH.
Journal article
Wilson AD. et al, (2021), Cardiovasc Res
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Energetic Basis for Exercise-Induced Pulmonary Congestion in Heart Failure With Preserved Ejection Fraction.
Journal article
Burrage MK. et al, (2021), Circulation, 144, 1664 - 1678
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Intentional Weight Loss as a Novel Treatment for Heart Failure with Preserved Ejection Fraction
Conference paper
Hundertmark MJ. et al, (2021), CIRCULATION, 144
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Myocardial Energetic Impairment is the Basis for Reduced Cardiac Reserve and Exercise-Induced Pulmonary Congestion in Heart Failure With Preserved Ejection Fraction: Insights From Novel Cardiopulmonary Magnetic Resonance Imaging
Conference paper
Burrage MK. et al, (2021), CIRCULATION, 144
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Frequency drift in MR spectroscopy at 3T.
Journal article
Hui SCN. et al, (2021), Neuroimage, 241
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A simple, open and extensible gating Control unit for cardiac and respiratory synchronisation control in small animal MRI and demonstration of its robust performance in steady-state maintained CINE-MRI.
Journal article
Gilchrist S. et al, (2021), Magn Reson Imaging, 81, 1 - 9
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Diabetic mitochondria are resistant to palmitoyl CoA inhibition of respiration, which is detrimental during ischemia.
Journal article
Kerr M. et al, (2021), FASEB J, 35
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Maternal iron deficiency perturbs embryonic cardiovascular development in mice.
Journal article
Kalisch-Smith JI. et al, (2021), Nature communications, 12
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Maternal iron deficiency perturbs embryonic cardiovascular development in mice.
Journal article
Kalisch-Smith JI. et al, (2021), Nat Commun, 12
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Elevated myocardial fructose and sorbitol levels are associated with diastolic dysfunction in diabetic patients, and cardiomyocyte lipid inclusions in vitro
Journal article
Daniels LJ. et al, (2021), Nutrition & Diabetes, 11
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Proof-of-Principle Demonstration of Direct Metabolic Imaging Following Myocardial Infarction Using Hyperpolarized 13C CMR.
Journal article
Apps A. et al, (2021), JACC Cardiovasc Imaging, 14, 1285 - 1288
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Rapid, B 1 -insensitive, dual-band quasi-adiabatic saturation transfer with optimal control for complete quantification of myocardial ATP flux.
Journal article
Miller JJ. et al, (2021), Magn Reson Med, 85, 2978 - 2991
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Association of Left Ventricular Global Longitudinal Strain With Cardiac Amyloid Load in Light Chain Amyloidosis
Journal article
Kim D. et al, (2021), JACC: Cardiovascular Imaging, 14, 1283 - 1285
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IMPAIRED MYOCARDIAL ENERGETICS AS THE BASIS FOR EXERCISE-INDUCED PULMONARY CONGESTION IN HEART FAILURE WITH PRESERVED EJECTION FRACTION
Conference paper
Burrage MK. et al, (2021), HEART, 107, A177 - A177
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Probing hepatic metabolism of [2-13C]dihydroxyacetone in vivo with 1H-decoupled hyperpolarized 13C-MR.
Journal article
Marco-Rius I. et al, (2021), MAGMA, 34, 49 - 56
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A 3D hybrid-shot spiral sequence for hyperpolarized 13 C imaging.
Journal article
Tyler A. et al, (2021), Magn Reson Med, 85, 790 - 801
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Fructose Metabolism and Cardiac Metabolic Stress.
Journal article
Annandale M. et al, (2021), Front Pharmacol, 12
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Magnetic Resonance pH Imaging in Stroke - Combining the Old With the New.
Journal article
Larkin JR. et al, (2021), Front Physiol, 12
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HP acquisition methods: pulse sequences, reconstruction, and RF coils
Chapter
Gordon JW. and Miller JJ., (2021), Advances in Magnetic Resonance Technology and Applications, 49 - 74
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Metabolic Effects of Doxorubicin on the Rat Liver Assessed With Hyperpolarized MRI and Metabolomics.
Journal article
Timm KN. et al, (2021), Front Physiol, 12
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Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI.
Journal article
Timm KN. et al, (2020), Commun Biol, 3
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Nicotinic acid receptor agonists impair myocardial contractility by energy starvation.
Journal article
Watson WD. et al, (2020), FASEB J, 34, 14878 - 14891
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Effects of contrast agents on relaxation properties of 31P metabolites.
Journal article
Valkovič L. et al, (2020), Magn Reson Med
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Rescue of myocardial energetic dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol.
Journal article
Kerr M. et al, (2020), JCI Insight, 5
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Modifying nutritional substrates induces macrovesicular lipid droplet accumulation and metabolic alterations in a cellular model of hepatic steatosis.
Journal article
Gunn PJ. et al, (2020), Physiol Rep, 8
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Cardiac Energetics in Patients With Aortic Stenosis and Preserved Versus Reduced Ejection Fraction.
Journal article
Peterzan MA. et al, (2020), Circulation, 141, 1971 - 1985
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Use of cardiac magnetic resonance to detect changes in metabolism in heart failure.
Journal article
Watson WD. et al, (2020), Cardiovasc Diagn Ther, 10, 583 - 597
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Hyperpolarized 13C MRI: A novel approach for probing cerebral metabolism in health and neurological disease.
Journal article
Grist JT. et al, (2020), J Cereb Blood Flow Metab, 40, 1137 - 1147
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Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet.
Journal article
Kellard JA. et al, (2020), Mol Metab, 40
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Noninvasive In Vivo Assessment of Cardiac Metabolism in the Healthy and Diabetic Human Heart Using Hyperpolarized 13C MRI.
Journal article
Rider OJ. et al, (2020), Circ Res, 126, 725 - 736
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PYY, a Therapeutic Option for Type 2 Diabetes?
Journal article
Guida C. and Ramracheya R., (2020), Clinical Medicine Insights: Endocrinology and Diabetes, 13
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Somatostatin secretion by Na+-dependent Ca2+-induced Ca2+ release in pancreatic delta-cells.
Journal article
Vergari E. et al, (2020), Nat Metab, 2, 32 - 40
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Conditionally immortalized brown preadipocytes can switch between proliferative and differentiated states.
Journal article
Liu J. et al, (2019), Biochim Biophys Acta Mol Cell Biol Lipids, 1864
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A role for placental kisspeptin in β cell adaptation to pregnancy
Journal article
Bowe JE. et al, (2019), JCI Insight, 4
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A multidisciplinary approach to the management of NAFLD is associated with improvement in markers of liver and cardio-metabolic health.
Journal article
Moolla A. et al, (2019), Frontline Gastroenterol, 10, 337 - 346
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Water gated contrast switching with polymer-silica hybrid nanoparticles.
Journal article
Pellico J. et al, (2019), Chem Commun (Camb), 55, 8540 - 8543
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The effect of metformin on hepatic fatty acid partitioning; an investigation using human in vivo and in vitro models
Conference paper
Green C. et al, (2019), JOURNAL OF HEPATOLOGY, 70, E794 - E795
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SGLT2 inhibition does not reduce hepatic steatosis in overweight, insulin resistant patients without type 2 diabetes
Conference paper
Marjot T. et al, (2019), JOURNAL OF HEPATOLOGY, 70, E68 - E68
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PYY plays a key role in the resolution of diabetes following bariatric surgery in humans.
Journal article
Guida C. et al, (2019), EBioMedicine, 40, 67 - 76
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Mapping tissue water T1 in the liver using the MOLLI T1 method in the presence of fat, iron and B0 inhomogeneity.
Journal article
Mozes FE. et al, (2019), NMR Biomed, 32
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Large expert-curated database for benchmarking document similarity detection in biomedical literature search.
Journal article
Brown P. et al, (2019), Database (Oxford), 2019
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Author Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring.
Journal article
Sun W. et al, (2018), Nature medicine, 24
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Publisher Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring.
Journal article
Sun W. et al, (2018), Nature medicine, 24
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Liver biochemical abnormalities in Turner syndrome: A comprehensive characterization of an adult population.
Journal article
Calanchini M. et al, (2018), Clin Endocrinol (Oxf), 89, 667 - 676
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Hyperpolarized [1,4-13C2]Fumarate Enables Magnetic Resonance-Based Imaging of Myocardial Necrosis.
Journal article
Miller JJ. et al, (2018), JACC Cardiovasc Imaging, 11, 1594 - 1606
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13C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI.
Journal article
Miller JJ. et al, (2018), Sci Rep, 8
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Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS.
Journal article
Timm KN. et al, (2018), NMR Biomed, 31
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CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets.
Journal article
Briant LJB. et al, (2018), Cell Rep, 23, 3300 - 3311
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Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells.
Journal article
Hamilton A. et al, (2018), Diabetes, 67, 1128 - 1139
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Cardiac applications of hyperpolarised magnetic resonance.
Journal article
Timm KN. et al, (2018), Prog Nucl Magn Reson Spectrosc, 106-107, 66 - 87
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Hyperpolarized ketone body metabolism in the rat heart.
Journal article
Miller JJ. et al, (2018), NMR Biomed, 31
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Noninvasive Immunometabolic Cardiac Inflammation Imaging Using Hyperpolarized Magnetic Resonance.
Journal article
Lewis AJM. et al, (2018), Circ Res, 122, 1084 - 1093
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Susceptibility-induced distortion correction in hyperpolarized echo planar imaging.
Journal article
Miller JJ. et al, (2018), Magn Reson Med, 79, 2135 - 2141
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Sitagliptin and Roux-en-Y gastric bypass modulate insulin secretion via regulation of intra-islet PYY.
Journal article
Guida C. et al, (2018), Diabetes Obes Metab, 20, 571 - 581
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Protocols and Methodologies in Basic Science and Clinical Cardiac MRI
Book
(2018)
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Prevalence and severity of non-alcoholic fatty liver disease are underestimated in clinical practice: impact of a dedicated screening approach at a large university teaching hospital.
Journal article
Marjot T. et al, (2018), Diabet Med, 35, 89 - 98
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Weighted averaging in spectroscopic studies improves statistical power.
Journal article
Miller JJ. et al, (2017), Magn Reson Med, 78, 2082 - 2094
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Myocyte metabolic imaging with hyperpolarised MRI
Chapter
Miller JJ., (2017), Protocols and Methodologies in Basic Science and Clinical Cardiac MRI, 111 - 173
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The Role of PYY in Pancreatic Islet Physiology and Surgical Control of Diabetes.
Journal article
Guida C. et al, (2017), Trends Endocrinol Metab, 28, 626 - 636
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HYPERPOLARIZED MAGNETIC RESONANCE IMAGING OF CARDIAC INFLAMMATION AND REPAIR
Conference paper
Lewis AJM. et al, (2017), HEART, 103, A151 - A151
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The role of PYY in pancreatic islet physiology and surgical control of diabetes
Journal article
Guida C. et al, (2017), Trends in Endocrinology and Metabolism
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Mapping of intracellular pH in the in vivo rodent heart using hyperpolarized [1-13C]pyruvate.
Journal article
Lau AZ. et al, (2017), Magn Reson Med, 77, 1810 - 1817
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Hyperpolarised MRI of cardiac inflammation and repair
Poster
Lewis A. et al, (2017), LANCET, 389, 62 - 62
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On the Metabolism of Exogenous Ketones in Humans.
Journal article
Stubbs BJ. et al, (2017), Front Physiol, 8
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Simultaneous assessment of cardiac metabolism and perfusion using copolarized [1-13 C]pyruvate and 13 C-urea.
Journal article
Lau AZ. et al, (2017), Magn Reson Med, 77, 151 - 158
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Simultaneous in vivo assessment of cardiac and hepatic metabolism in the diabetic rat using hyperpolarized MRS.
Journal article
Le Page LM. et al, (2016), NMR Biomed, 29, 1759 - 1767
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Assessment of Metformin-Induced Changes in Cardiac and Hepatic Redox State Using Hyperpolarized[1-13C]Pyruvate.
Journal article
Lewis AJM. et al, (2016), Diabetes, 65, 3544 - 3551
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GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states.
Journal article
Veprik A. et al, (2016), FASEB J, 30, 3860 - 3869
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NON-INVASIVE ASSESSMENT OF METFORMIN INDUCED CHANGES IN CARDIAC AND HEPATIC REDOX STATE USING HYPERPOLARIZED [1-13C] PYRUVATE
Conference paper
Lewis AJM. et al, (2016), HEART, 102, A14 - A14
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Fast Padé Transform Accelerated CSI for Hyperpolarized MRS.
Journal article
Hansen ESS. et al, (2016), Tomography, 2, 117 - 124
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Robust and high resolution hyperpolarized metabolic imaging of the rat heart at 7 T with 3D spectral-spatial EPI.
Journal article
Miller JJ. et al, (2016), Magn Reson Med, 75, 1515 - 1524
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Cardiac perfusion imaging using hyperpolarized (13)C urea using flow sensitizing gradients.
Journal article
Lau AZ. et al, (2016), Magn Reson Med, 75, 1474 - 1483
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Imaging Bone-Cartilage Interactions in Osteoarthritis Using [18F]-NaF PET-MRI.
Journal article
Savic D. et al, (2016), Mol Imaging, 15, 1 - 12
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Modeling predicts a connection between sinus vortex effects and aortic compliance
Journal article
Aboelkassem Y. et al, (2016), Journal of Theoretical Biology, 389, 306 - 309
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Cartilage T 1ρ and T 2 relaxation times: longitudinal reproducibility and variations using different coils, MR systems and sites
Journal article
Li X. et al, (2015), Osteoarthritis and Cartilage, 23, 2214 - 2223
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In vivo assessment of cardiac metabolism and function in the abdominal aortic banding model of compensated cardiac hypertrophy.
Journal article
Seymour A-ML. et al, (2015), Cardiovasc Res, 106, 249 - 260
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Correction.
Journal article
(2015), Proc Natl Acad Sci U S A, 112
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Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function.
Journal article
Lakhal-Littleton S. et al, (2015), Proc Natl Acad Sci U S A, 112, 3164 - 3169
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Mathematical modeling of aortic valve dynamics during systole
Journal article
Aboelkassem Y. et al, (2015), Journal of Theoretical Biology, 365, 280 - 288
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Assessing Biological Response to Bevacizumab Using 18F-Fluoromisonidazole PET/MR Imaging in a Patient with Recurrent Anaplastic Astrocytoma
Journal article
Barajas RF. et al, (2015), Case Reports in Radiology, 2015, 1 - 4
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The effect of magnetic field on positron range and spatial resolution in an integrated whole-body time-of-flight PET/MRI system
Journal article
Shih-ying Huang None. et al, (2014), 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)
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Mechanisms of cell migration in the adult brain: modelling subventricular neurogenesis.
Journal article
Van Schepdael A. et al, (2013), Comput Methods Biomech Biomed Engin, 16, 1096 - 1105
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The role of lycopene and its derivatives in the regulation of transcription systems: implications for cancer prevention.
Journal article
Sharoni Y. et al, (2012), Am J Clin Nutr, 96, 1173S - 1178S
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A mathematical model of adult subventricular neurogenesis.
Journal article
Ashbourn JMA. et al, (2012), J R Soc Interface, 9, 2414 - 2423
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Polyphenols, isothiocyanates, and carotenoid derivatives enhance estrogenic activity in bone cells but inhibit it in breast cancer cells.
Journal article
Veprik A. et al, (2012), Am J Physiol Endocrinol Metab, 303, E815 - E824
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GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.
Journal article
Bahar Halpern K. et al, (2012), J Biol Chem, 287, 20154 - 20163
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Carotenoids and apocarotenoids in cellular signaling related to cancer: a review.
Journal article
Sharoni Y. et al, (2012), Mol Nutr Food Res, 56, 259 - 269