Fellows' Publications
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PYY plays a key role in the resolution of diabetes following bariatric surgery in humans.
Guida C. et al, (2019), EBioMedicine, 40, 67 - 76
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Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion.
Vergari E. et al, (2019), Nat Commun, 10
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Sitagliptin and Roux-en-Y gastric bypass modulate insulin secretion via regulation of intra-islet PYY.
Guida C. et al, (2018), Diabetes Obes Metab, 20, 571 - 581
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CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets.
Briant LJB. et al, (2018), Cell Rep, 23, 3300 - 3311
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Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production.
Knudsen JG. et al, (2019), Cell Metab, 29, 430 - 442.e4
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Cardiac applications of hyperpolarised magnetic resonance
Timm KN. et al, (2018), Progress in Nuclear Magnetic Resonance Spectroscopy, 106-107, 66 - 87
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Susceptibility-induced distortion correction in hyperpolarized echo planar imaging.
Miller JJ. et al, (2018), Magn Reson Med, 79, 2135 - 2141
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13C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI.
Miller JJ. et al, (2018), Sci Rep, 8
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Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS.
Timm KN. et al, (2018), NMR Biomed, 31
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The role of PYY in pancreatic islet physiology and surgical control of diabetes
Guida C. et al, (2017), Trends in Endocrinology and Metabolism
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Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.
Lotta LA. et al, (2017), Nat Genet, 49, 17 - 26
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A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.
Manning A. et al, (2017), Diabetes, 66, 2019 - 2032
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Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.
Yavari A. et al, (2016), Cell Metab, 23, 821 - 836
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Optimizing human hepatocyte models for metabolic phenotype and function: effects of treatment with dimethyl sulfoxide (DMSO).
Nikolaou N. et al, (2016), Physiol Rep, 4
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Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants.
Thomsen SK. et al, (2016), Diabetes, 65, 3805 - 3811
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The genetic architecture of type 2 diabetes.
Fuchsberger C. et al, (2016), Nature, 536, 41 - 47
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Insights into islet development and biology through characterization of a human iPSC-derived endocrine pancreas model.
van de Bunt M. et al, (2016), Islets, 8, 83 - 95
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Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells.
Brereton MF. et al, (2016), Nat Commun, 7
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Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.
van de Bunt M. et al, (2015), PLoS Genet, 11