Fellows' Publications
PYY plays a key role in the resolution of diabetes following bariatric surgery in humans.
Guida C. et al, (2019), EBioMedicine, 40, 67 - 76
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion.
Vergari E. et al, (2019), Nat Commun, 10
Sitagliptin and Roux-en-Y gastric bypass modulate insulin secretion via regulation of intra-islet PYY.
Guida C. et al, (2018), Diabetes Obes Metab, 20, 571 - 581
CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets.
Briant LJB. et al, (2018), Cell Rep, 23, 3300 - 3311
Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production.
Knudsen JG. et al, (2019), Cell Metab, 29, 430 - 442.e4
Cardiac applications of hyperpolarised magnetic resonance.
Timm KN. et al, (2018), Prog Nucl Magn Reson Spectrosc, 106-107, 66 - 87
Susceptibility-induced distortion correction in hyperpolarized echo planar imaging.
Miller JJ. et al, (2018), Magn Reson Med, 79, 2135 - 2141
13C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI.
Miller JJ. et al, (2018), Sci Rep, 8
Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS.
Timm KN. et al, (2018), NMR Biomed, 31
The role of PYY in pancreatic islet physiology and surgical control of diabetes
Guida C. et al, (2017), Trends in Endocrinology and Metabolism
Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.
Lotta LA. et al, (2017), Nat Genet, 49, 17 - 26
A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.
Manning A. et al, (2017), Diabetes, 66, 2019 - 2032
Decreased STARD10 expression is associated with defective insulin secretion in humans and mice
Carrat G. et al, (2017)
Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.
Yavari A. et al, (2016), Cell Metab, 23, 821 - 836
Optimizing human hepatocyte models for metabolic phenotype and function: effects of treatment with dimethyl sulfoxide (DMSO).
Nikolaou N. et al, (2016), Physiol Rep, 4
Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants.
Thomsen SK. et al, (2016), Diabetes, 65, 3805 - 3811
Insights into islet development and biology through characterization of a human iPSC-derived endocrine pancreas model.
van de Bunt M. et al, (2016), Islets, 8, 83 - 95
Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells.
Brereton MF. et al, (2016), Nat Commun, 7
Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.
van de Bunt M. et al, (2015), PLoS Genet, 11