We work on circadian rhythms, and nuclear receptors applied to both inflammation and energy metabolism. Our models range from cells to human populations.
We are interested in control systems operating on energy metabolism, and also on inflammation. Disorders of these processes underpin many prevalent human diseases. We focused attention on nuclear receptor biology which is fundamental to regulating both systems, and in particular the glucocorticoid receptor. As it became clear that the glucocorticoid signalling network was intimately connected to the circadian timing machinery operating in peripheral tissues our research expanded to examine circadian biology.
- Andrew Loudon
- David Bechtold
- Julie Gibbs
- Hannah Durrington
- John Blaikley, (NIH, Washington DC, USA)
- Gordon Hager