Nuffield Division of Clinical Laboratory Sciences
Head of Division
About NDCLS
Our aim is to study the pathology of human disease from the molecular to systems level, and to translate our findings into treatments for human disorders.
Read moreGene Therapy for Cystic Fibrosis
Professors Deborah Gill and Stephen Hyde, together with their UK Cystic Fibrosis Gene Therapy Consortium partners, have teamed up with Boehringer Ingelheim and Oxford Biomedica to develop gene therapy for cystic fibrosis.
Read moreDisruptive bioengineering – changing the way cells interact with each other
Researchers at the MRC Weatherall Institute of Molecular Medicine have developed a new platform based on CRISPR/Cas9 technology, to alter the way human cells respond to external signals.
Read moreOxford Centre for Haematology Launched
The Radcliffe Department of Medicine has launched a new initiative – the Oxford Centre for Haematology (OCH). Through this virtual Centre we aim to promote integration between academic and clinical haematology programmes in the University and Oxford University Hospital NHS Foundation Trust and thereby capitalise on scientific opportunities to transform our understanding of haemopoiesis and blood diseases.
Read moreLatest Publications
Phenotypic and molecular characterization of a serum-free miniature erythroid differentiation system suitable for high-throughput screening and single-cell assays.
Mettananda S. et al, (2018), Exp Hematol, 60, 10 - 20
Genome and epigenome engineering CRISPR toolkit for in vivo modulation of cis-regulatory interactions and gene expression in the chicken embryo.
Williams RM. et al, (2018), Development, 145
Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia.
Mettananda S. et al, (2017), Nat Commun, 8
Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response.
Amatangelo MD. et al, (2017), Blood, 130, 732 - 741
Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia.
Stein EM. et al, (2017), Blood, 130, 722 - 731
The Latest News
TP53 gene determines severe blood cancer development
13 August 2020
New RDM Associate Professors and University Research Lecturers
10 July 2020
Many congratulations to our researchers.