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'Go with the flow' captures the blood flowing within an adult heart frozen in time. It won the 2016 Reflections on Research competition, run by the British Heart Foundation. Victoria Stoll, Oxford
'Go with the flow' captures the blood flowing within an adult heart frozen in time. It won the 2016 Reflections on Research competition, run by the British Heart Foundation.

We aim to better understand, diagnose and treat heart and vascular disease through our extensive cutting edge research programmes. We have a particular focus on understanding disease mechanisms and on new approaches to stratifying patients. Our expertise encompasses genetic studies to identify causative and risk genes, cardiovascular physiology and cellular biology to understand health and disease, the development and application of advanced imaging, experimental medicine and clinical trials.

Our research integrates basic and clinical research to maximise patient benefit. This theme incorporates three state of the art clinical research facilities – the Clinical Cardiovascular Research Facility, the Oxford Centre for Clinical Magnetic Resonance Research and the Acute Vascular Imaging Centre. Combined, these facilities give us a comprehensive view of cardiovascular physiology, metabolism and function in health and disease.

Our researchers lead the NIHR Oxford Biomedical Research Centre's Cardiovascular Theme and the British Heart Foundation's Centre for Research Excellence, as well as being  key collaborators in the British Heart Foundation's Centre for Regenerative Medicine, widening opportunities for collaboration.

Groups within this theme

BHF Centres

The BHF Centre of Research Excellence (BHF CRE) in Oxford brings together over 60 world leading clinical and basic science research groups, based in departments across the University of Oxford.

The Oxbridge BHF Centre of Regenerative Medicine (BHF CRM) brings together 26 world leading basic and translational research groups (13 based in Oxford, 12 based in Cambridge, and one based in Bristol) merging significant expertise in cardiovascular repair and regeneration (Oxford), wound healing (Bristol), with a major focus on stem cells (ESCs and iPSCs) and genetics in the context of regeneration (Cambridge).

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Cardiovascular Science DPhil Projects

Assigning Functional Mechanisms to a New Coronary Artery Susceptibility Gene

Brown adipose tissue WNT signalling as a therapeutic target for obesity and type 2 diabetes

Cardiac energetics as a translational target for heart disease

Defining human hepatic insulin resistance

Engineered induced pluripotent stem cell lines for phenotypic selection of cardiac cell types

Exploring the role of Z-disk structure and signalling for striated muscle integrity with the help of genome-edited mouse models of cardiomyopathy

Functional analyses of newly implicated genes for inherited heart muscle diseases

Functional genomic analysis of genetic susceptibility loci for coronary artery disease

Go with the Flow: An integrative approach to study cardiovascular disease

Heterogeneity of heritable risk in coronary disease

Identification of the atrial transcriptional signature of patients who develop atrial fibrillation

Identifying new molecular players determining metabolic disease risk and susceptibility to osteoporosis 

Imaging in Preventive Cardiology Research

The influence of dietary fatty acids on regional adipose tissue development and function

Investigating the role of calcitonin in electrophysiological function in cardiomyocytes

Investigating the role of non-coding RNAs in fibrogenesis

Molecular mechanism of familial partial lipodystrophy

Role of homoarginine in cardiac health and disease

A role of long non-coding RNA loc554202 in atrial fibrosis

Screening for novel mechanosensors in cardiovascular disease

Whole genome sequencing to identify new disease genes for hypertrophic cardiomyopathy

All DPhil projects