Reversible pH-responsive MRI contrast with paramagnetic polymer micelles.

Ellis CM., Yuan D., Mózes FE., Miller JJ., Davis JJ.

Paramagnetically-doped polymer micelles, containing an ionizable poly(acrylic acid) (PAA) block, support high-contrast MR imaging at clinically relevant field strengths in a manner that is strongly pH responsive. A reversible switch in polymer strand charge specifically has a direct impact on local rigidity, and rotational correlation time characteristics, of the integrated Gd-chelate, driving a ∼50% amplitude switch in positive contrast.

DOI

10.1039/d2cc06255k

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

19/01/2023

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