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James Davies

DPhil, MRCP


MRC Clinician Scientist and Honorary Consultant Haematologist

Biography

I am a clinician scientist with a specialist interest in haemopoietic stem cell transplantation, genome editing, genomics and bioinformatics. I studied medicine at Oxford University before going on to complete specialist training in haematology and intensive care medicine in London. At present I have an MRC Clinician Scientist Fellowship and I am setting up a group at the Weatherall Institute of Molecular Medicine. In addition, I am an honorary consultant haematologist with the allogeneic transplant service in Oxford.

My research focuses on developing novel next generation sequencing-based methods for interrogating how the genome functions and leveraging this to develop methods of genome editing bone marrow derived stem cells. I have a particular interest in developing methods that allow the physical structure of DNA in the nucleus to be defined.  With Jim Hughes and Doug Higgs I developed the Capture-C method. This technique lead to insights into how genes are controlled and I was awarded the RDM Graduate Prize for this project. I am also interested in using genome editing of bone marrow derived stem cells to treat disease. In particular, I am using my previous expertise in bioinformatics to and high throughput sequencing to develop new ways of defining off target effects from genome editing.