Publications — Radcliffe Department of Medicine

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The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes.

Hua P. et al, (2020), Blood

CaptureCompendium: a comprehensive toolkit for 3C analysis

Telenius J. et al, (2020)

Single-cell analysis of bone marrow-derived CD34+ cells from children with sickle cell disease and thalassemia.

Hua P. et al, (2019), Blood, 134, 2111 - 2115

BET inhibition disrupts transcription but retains enhancer-promoter contact

Crump N. et al, (2019)

An integrated platform to systematically identify causal variants and genes for polygenic human traits

Downes D. et al, (2019)

Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland.

Cacciottolo TM. et al, (2019), QJM, 112, 724 - 729

The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist.

van Bemmel JG. et al, (2019), Nat Genet, 51, 1024 - 1034

Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains.

Oudelaar AM. et al, (2018), Nat Genet, 50, 1744 - 1751

Expression of the Human Alpha-Globin Cluster in the Absence of the Major Regulatory Element Mcs-R2

Badat M. et al, (2018), BLOOD, 132

Macrophage activation syndrome and post-transplant microangiopathy following haploidentical bone marrow transplantation for sickle cell anemia.

Davies JOJ. et al, (2018), Am J Hematol, 93, 588 - 589

HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis.

Yan T. et al, (2018), Nat Commun, 9

Robust detection of chromosomal interactions from small numbers of cells using low-input Capture-C.

Oudelaar AM. et al, (2017), Nucleic Acids Res, 45

Low-input Capture-C: A Chromosome Conformation Capture Assay to Analyze Chromatin Architecture in Small Numbers of Cells.

Oudelaar AM. et al, (2017), Bio Protoc, 7

VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.

Yao X. et al, (2017), Cancer Discov, 7, 1284 - 1305

Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element.

Huang P. et al, (2017), Genes Dev, 31, 1704 - 1713

Gene Therapy in a Patient with Sickle Cell Disease.

Badat M. and Davies J., (2017), N Engl J Med, 376, 2093 - 2094

MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylation.

Godfrey L. et al, (2017), Exp Hematol, 47, 64 - 75

How best to identify chromosomal interactions: a comparison of approaches.

Davies JOJ. et al, (2017), Nat Methods, 14, 125 - 134

Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters.

Platt JL. et al, (2016), EMBO Rep, 17, 1410 - 1421

Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity.

Ooi WF. et al, (2016), Nat Commun, 7

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