Publications — Radcliffe Department of Medicine

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Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF.

Aljahani A. et al, (2022), Nat Commun, 13

Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture.

Downes DJ. et al, (2022), Nat Protoc

Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus

DOWNES D. et al, (2021), Nature Genetics

Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus.

Downes DJ. et al, (2021), Nat Genet, 53, 1606 - 1615

Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF

Aljahani A. et al, (2021)

Reactivation of a developmentally silenced embryonic globin gene.

King AJ. et al, (2021), Nat Commun, 12

Defining genome architecture at base-pair resolution.

Hua P. et al, (2021), Nature, 595, 125 - 129

A remarkable case of HbH disease illustrates the relative contributions of the alpha-globin enhancers to gene expression (vol 137, pg 572, 2021)

Badat M. et al, (2021), BLOOD, 137, 2854 - 2854

A remarkable case of HbH disease illustrates the relative contributions of the α-globin enhancers to gene expression.

Badat M. et al, (2021), Blood, 137, 572 - 575

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale.

Downes DJ. et al, (2021), Nat Commun, 12

BET inhibition disrupts transcription but retains enhancer-promoter contact.

Crump NT. et al, (2021), Nat Commun, 12

The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes.

Hua P. et al, (2020), Blood, 136, 2410 - 2415

Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder.

Long HK. et al, (2020), Cell Stem Cell, 27, 765 - 783.e14

Targeted high-resolution chromosome conformation capture at genome-wide scale

Downes DJ. et al, (2020)

CaptureCompendium: a comprehensive toolkit for 3C analysis

Telenius J. et al, (2020)

Single-cell analysis of bone marrow-derived CD34+ cells from children with sickle cell disease and thalassemia.

Hua P. et al, (2019), Blood, 134, 2111 - 2115

BET inhibition disrupts transcription but retains enhancer-promoter contact

Crump N. et al, (2019)

An integrated platform to systematically identify causal variants and genes for polygenic human traits

Downes D. et al, (2019)

Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland.

Cacciottolo TM. et al, (2019), QJM, 112, 724 - 729

The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist.

van Bemmel JG. et al, (2019), Nat Genet, 51, 1024 - 1034

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