Publications — Radcliffe Department of Medicine

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An integrated platform to systematically identify causal variants and genes for polygenic human traits

Downes D. et al, (2019)

Single cell analysis of bone marrow derived CD34+ cells from children with sickle cell disease and thalassemia

Hua P. et al, (2019), Blood

The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist.

van Bemmel JG. et al, (2019), Nat Genet, 51, 1024 - 1034

Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains.

Oudelaar AM. et al, (2018), Nat Genet, 50, 1744 - 1751

Expression of the Human Alpha-Globin Cluster in the Absence of the Major Regulatory Element Mcs-R2

Badat M. et al, (2018), BLOOD, 132

Macrophage activation syndrome and post-transplant microangiopathy following haploidentical bone marrow transplantation for sickle cell anemia.

Davies JOJ. et al, (2018), Am J Hematol, 93, 588 - 589

HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis.

Yan T. et al, (2018), Nat Commun, 9

Robust detection of chromosomal interactions from small numbers of cells using low-input Capture-C.

Oudelaar AM. et al, (2017), Nucleic Acids Res, 45

Low-input Capture-C: A Chromosome Conformation Capture Assay to Analyze Chromatin Architecture in Small Numbers of Cells.

Oudelaar AM. et al, (2017), Bio Protoc, 7

VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.

Yao X. et al, (2017), Cancer Discov, 7, 1284 - 1305

Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element.

Huang P. et al, (2017), Genes Dev, 31, 1704 - 1713

Gene Therapy in a Patient with Sickle Cell Disease.

Badat M. and Davies J., (2017), N Engl J Med, 376, 2093 - 2094

MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylation.

Godfrey L. et al, (2017), Exp Hematol, 47, 64 - 75

How best to identify chromosomal interactions: a comparison of approaches.

Davies JOJ. et al, (2017), Nat Methods, 14, 125 - 134

Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters.

Platt JL. et al, (2016), EMBO Rep, 17, 1410 - 1421

Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity.

Ooi WF. et al, (2016), Nat Commun, 7

Genetic dissection of the α-globin super-enhancer in vivo.

Hay D. et al, (2016), Nat Genet, 48, 895 - 903

Unlinking an lncRNA from Its Associated cis Element.

Paralkar VR. et al, (2016), Mol Cell, 62, 104 - 110

Predicting the three-dimensional folding of cis-regulatory regions in mammalian genomes using bioinformatic data and polymer models.

Brackley CA. et al, (2016), Genome Biol, 17

Outcomes of Allogeneic Hematopoietic Cell Transplantation in Patients with Myelofibrosis with Prior Exposure to Janus Kinase 1/2 Inhibitors.

Shanavas M. et al, (2016), BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 22, 432 - 440

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