Publications — Radcliffe Department of Medicine

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Focal deletions of a promoter tether activate the IRX3 oncogene in T-cell acute lymphoblastic leukemia.

Rahman S. et al, (2024), Blood

The state-of-the-art of N-of-1 therapies and the IRDiRC N-of-1 development roadmap

DAVIES J., (2024), Nature Reviews Drug Discovery

Single-cell technologies meet Hi-C.

Hughes JR. and Davies JOJ., (2024), Nat Genet

Pioneer activity distinguishes activating from non-activating SOX2 binding sites.

Maresca M. et al, (2023), EMBO J

MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia.

Crump NT. et al, (2023), Nat Commun, 14

Author Correction: Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture.

Downes DJ. et al, (2023), Nat Protoc

GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells.

Turkalj S. et al, (2023), Cell Stem Cell, 30, 722 - 740.e11

Direct correction of haemoglobin E β-thalassaemia using base editors.

Badat M. et al, (2023), Nat Commun, 14

Determining chromatin architecture with Micro Capture-C.

Hamley JC. et al, (2023), Nat Protoc

Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features.

Robbe P. et al, (2022), Nat Genet, 54, 1675 - 1689

Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF.

Aljahani A. et al, (2022), Nat Commun, 13

Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture.

Downes DJ. et al, (2022), Nat Protoc

Genotyping of Multiple Genomic Loci with Chromatin Accessibility Profiling in Single Cells Links Clonal Hierarchy with Epigenetic Variation in Acute Myeloid Leukemia

Turkalj S. et al, (2022), BLOOD, 140, 1193 - 1194

Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus

DOWNES D. et al, (2021), Nature Genetics

Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus.

Downes DJ. et al, (2021), Nat Genet, 53, 1606 - 1615

Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF

Aljahani A. et al, (2021)

Reactivation of a developmentally silenced embryonic globin gene.

King AJ. et al, (2021), Nat Commun, 12

Defining genome architecture at base-pair resolution.

Hua P. et al, (2021), Nature, 595, 125 - 129

A remarkable case of HbH disease illustrates the relative contributions of the alpha-globin enhancers to gene expression (vol 137, pg 572, 2021)

Badat M. et al, (2021), BLOOD, 137, 2854 - 2854

A remarkable case of HbH disease illustrates the relative contributions of the α-globin enhancers to gene expression.

Badat M. et al, (2021), Blood, 137, 572 - 575

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