We are a large multi-disciplinary department, which aims to tackle some of the world’s biggest health challenges by integrating innovative basic biology with cutting edge clinical research. We have internationally renowned programmes in a range of areas including cardiovascular sciences, diabetes and endocrinology, immunology, haematology and pathology.
Genome and epigenome engineering CRISPR toolkit forin vivomodulation ofcis-regulatory interactions and gene expression in the chicken embryo.
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MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A.
Howson LJ. et al, (2018), Nat Commun, 9
In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering.
Wu Q. et al, (2017), Nat Commun, 8
Karamitros D. et al, (2018), Nat Immunol, 19, 85 - 97
Appari M. et al, (2017), Antioxid Redox Signal