Nuffield Division of Clinical Laboratory Sciences
Our aim is to study the pathology of human disease from the molecular to systems level, and to translate our findings into treatments for human disorders.
Phenotypic and molecular characterization of a serum-free miniature erythroid differentiation system suitable for high-throughput screening and single-cell assays.
Mettananda S. et al, (2018), Exp Hematol, 60, 10 - 20
Genome and epigenome engineering CRISPR toolkit forin vivomodulation ofcis-regulatory interactions and gene expression in the chicken embryo.
Williams RM. et al, (2018), Development, 145
Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia.
Mettananda S. et al, (2017), Nat Commun, 8
Amatangelo MD. et al, (2017), Blood, 130, 732 - 741
Stein EM. et al, (2017), Blood, 130, 722 - 731