Nuffield Division of Clinical Laboratory Sciences
Head of Division
About NDCLS
Our aim is to study the pathology of human disease from the molecular to systems level, and to translate our findings into treatments for human disorders.
Read moreLatest Publications
Phenotypic and molecular characterization of a serum-free miniature erythroid differentiation system suitable for high-throughput screening and single-cell assays.
Mettananda S. et al, (2018), Exp Hematol, 60, 10 - 20
Genome and epigenome engineering CRISPR toolkit for in vivo modulation of cis-regulatory interactions and gene expression in the chicken embryo.
Williams RM. et al, (2018), Development, 145
Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia.
Mettananda S. et al, (2017), Nat Commun, 8
Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response.
Amatangelo MD. et al, (2017), Blood, 130, 732 - 741
Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia.
Stein EM. et al, (2017), Blood, 130, 722 - 731
The Latest News
Changes in blood cell production over the human lifetime may hold clues to patterns of disease
16 September 2021
A new paper published this week in Cell Reports reveals that changes in the gene expression of blood stem cells occur across the human lifetime; an important step in the understanding and treatment of blood disorders.