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- Buchan Group: Laboratory of Cerebral Ischemia Research Group
BSc (Hons), MSc, DPhil
My primary research field is neuroimmunology, specifically how the brain communicates injury or illness to the systemic immune system, and vice-versa. I am currently studying how injury signals might escape the brain after a stroke, with a particular focus on extracellular vesicles (EVs). EVs are small fragments of cell membrane, shed from cells all the time, and thought to be a novel mechanism of cell to cell communication. My aim is to study whether these EVs contribute to inflammation within the central nervous system (CNS) after a stroke, but also whether they contribute to the injury signal that activates the systemic immune system.
Exacerbation of Acute Traumatic Brain Injury by Circulating Extracellular Vesicles.
Hazelton I. et al, (2018), J Neurotrauma
Circulating endothelial cell-derived extracellular vesicles mediate the acute phase response and sickness behaviour associated with CNS inflammation.
Couch Y. et al, (2017), Sci Rep, 7
Neuroprotection in stroke: the importance of collaboration and reproducibility.
Neuhaus AA. et al, (2017), Brain, 140, 2079 - 2092
Inflammatory Stroke Extracellular Vesicles Induce Macrophage Activation.
Couch Y. et al, (2017), Stroke, 48, 2292 - 2296
Multi-modal assessment of neurovascular coupling during cerebral ischaemia and reperfusion using remote middle cerebral artery occlusion.
Sutherland BA. et al, (2017), J Cereb Blood Flow Metab, 37, 2494 - 2508