DPhil projects available

Cardiac energetics as a translational target for heart disease

Role of homoarginine in cardiac health and disease

https://www.spc.ox.ac.uk/people/academic/dr-sevasti-zervou

 Career

My research career started at the University of Warwick where I completed my PhD in Molecular Medicine, working on nitric oxide synthase signalling in the uterine smooth muscle. I then carried on working at Warwick on multi-disciplinary projects in the area of Molecular Endocrinology, until I took up a Research Fellow role in Cardiovascular Diabetes and Metabolism, funded by the Wellcome (2005-2009).  

I joined the Lygate/Neubauer Group at the Division of Cardiovascular Medicine in 2009 as part of the Basic Science team, funded by the British Heart Foundation.

I am a graduate student co- supervisor (2010-) and RDM mentor to junior colleagues. Other University activities include graduate student selection, peer review for several Journals, being a member of the Congregation and of the RDM Athena SWAN Environment and Culture Committee. I have taken part in several public engagement activities since 2019, talking to secondary school pupils about cardiovascular research and science careers.

Research Expertise and Interests 

A substantial part of my work since 2009 is screening for small molecules towards identification of pharmacological tools for manipulation of myocardial creatine content (BHF CRE pump priming award 2010-2013). This work has involved setting up primary assays (for example enzymatic or reporter) and identifying positive hits to be tested through secondary and counter screens. It is an ongoing project in collaboration with industry.  

ORCID 0000-0002-4665-2747