Research groups
Colleges
Sevasti Zervou
BSc (Hons); PhD
Senior Researcher and Stipendiary Lecturer in Biochemistry
- Senior Researcher, Cardiovascular Medicine
- Stipendiary Lecturer in Cellular Biochemistry, St. Peter's College
Molecular and cellular aspects of heart metabolism
Career
My research career started at the University of Warwick where I completed my PhD in Molecular Medicine, and then took up a Research Fellow position in Endocrinology and Diabetes until 2009. I then joined the Neubauer/Lygate Group in the Division of Cardiovascular Medicine as a Senior Researcher, funded by the British Heart Foundation.
My expertise lies within cell-based approaches to investigate and boost cellular energetics in the heart. Towards this goal, and jointly with the rest of our team I have developed in-house assays and contributed with generating in vitro and in vivo models of genetic manipulation. Other aspects of the work involve molecular phenotyping, protein post-translational modifications and -omics studies/analyses.
Since 2021 I am a Stipendiary Lecturer in Cellular Biochemistry at St. Peter's College, Oxford, teaching Signalling, Metabolism, Cell structure and organisation to undergraduate students.
I am an official co-supervisor to graduate students (2010-) and RDM mentor to junior colleagues and involved in several Departmental and University-wide activities, member of the Congregation and RDM Athena SWAN Environment and Culture Committee. Since 2018 I have taken part in public engagement talking to secondary school and Sixth form pupils about cardiovascular research and science careers, both in person and via webinars.
ORCID 0000-0002-4665-2747
Sevasti Zervou — University of Oxford, Medical Sciences Division
Key publications
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Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro.
Journal article
Zervou S. et al, (2017), PLoS One, 12
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AUGMENTATION OF CREATINE KINASE IN VITRO PROTECTS AGAINST SIMULATED ISCHAEMIA REPERFUSION INJURY
Conference paper
Zervou S. et al, (2017), HEART, 103, A144 - A144
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Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms.
Journal article
Zervou S. et al, (2016), Amino Acids, 48, 1969 - 1981
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Augmentation of Creatine in the Heart.
Journal article
Zervou S. et al, (2016), Mini Rev Med Chem, 16, 19 - 28
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A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis.
Journal article
Zervou S. et al, (2013), Am J Physiol Endocrinol Metab, 305, E263 - E270
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Living without creatine: Unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice
Journal article
Lygate CA. et al, (2013), Circulation Research, 112, 945 - 955
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Short-term hyperglycaemia causes non-reversible changes in arterial gene expression in a fully 'switchable' in vivo mouse model of diabetes.
Journal article
Zervou S. et al, (2010), Diabetologia, 53, 2676 - 2687
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Role of hyperglycaemia in pathogenesis of diabetic cardiovascular disease
Journal article
Zervou S. and Khan M., (2007), Vascular Disease Prevention, 4, 125 - 139
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Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines.
Journal article
Chen J. et al, (2006), Diabetologia, 49, 1292 - 1302
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Progesterone signaling in human myometrium through two novel membrane G protein-coupled receptors: potential role in functional progesterone withdrawal at term.
Journal article
Karteris E. et al, (2006), Mol Endocrinol, 20, 1519 - 1534