Sevasti Zervou

• AUGMENTATION OF CREATINE KINASE IN VITRO PROTECTS AGAINST SIMULATED ISCHAEMIA REPERFUSION INJURY

  Zervou S. et al, (2017), HEART, 103, A144 - A144

• Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure.

  Atzler D. et al, (2017), Circulation, 135, 400 - 402

• Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro.

  Zervou S. et al, (2017), PLoS One, 12

• Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms.

  Zervou S. et al, (2016), Amino Acids, 48, 1969 - 1981

• Augmentation of Creatine in the Heart.

  Zervou S. et al, (2016), Mini Rev Med Chem, 16, 19 - 28

• LOSS OF HOMOARGININE IS RESPONSIBLE FOR CARDIAC DYSFUNCTION IN CREATINE-DEFICIENT ARGININE: GLYCINE AMIDINOTRANSFERASE (AGAT) KNOCKOUT MICE

  Whittington HJ. et al, (2014), HEART, 100

• Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity.

  Aksentijević D. et al, (2014), J Mol Cell Cardiol, 75, 76 - 87

• Metabolic Inflexibility of Malonyl CoA Decarboxylase (MCD) Knockout Mice Leads to Cardiac Remodelling and High Mortality During Peri-Weaning Period

  Aksentijevic D. et al, (2014), BIOPHYSICAL JOURNAL, 106, 187A - 187A

• Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart.

  Aksentijević D. et al, (2014), PLoS One, 9

• Chronic Creatine-deficiency is not the Underlying Cause of Cardiac Dysfunction in Mice Lacking the Creatine Biosynthetic Enzyme Arginine: glycine Amidinotransferase

  Lygate CA. et al, (2013), CIRCULATION, 128

• A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis.

  Zervou S. et al, (2013), Am J Physiol Endocrinol Metab, 305, E263 - E270

• REGULATION OF CELLULAR CREATINE HOMEOSTASIS: A ROLE FOR THIOREDOXIN INTERACTING PROTEIN (TXNIP)

  Zervou S. et al, (2013), HEART, 99, A117 - A117

• Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.

  Lygate CA. et al, (2013), Circ Res, 112, 945 - 955

• Living without creatine: Unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice

  Lygate CA. et al, (2013), Circulation Research, 112, 945 - 955

• Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction.

  Lygate CA. et al, (2012), Cardiovasc Res, 96, 466 - 475

• Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age.

  Lygate CA. et al, (2012), Basic Res Cardiol, 107

• Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age

  Lygate CA. et al, (2012), Basic Research in Cardiology, 107

• Elevated Myocardial Creatine Protects Against Ischemia/Reperfusion Injury by Improving Cardiac Energetics

  Lygate CA. et al, (2011), CIRCULATION, 124

• Short-term hyperglycaemia causes non-reversible changes in arterial gene expression in a fully 'switchable' in vivo mouse model of diabetes.

  Zervou S. et al, (2010), Diabetologia, 53, 2676 - 2687

• High-energy phosphotransfer in the failing mouse heart: role of adenylate kinase and glycolytic enzymes.

  Aksentijević D. et al, (2010), Eur J Heart Fail, 12, 1282 - 1289

• Creatine reduces mitochondrial permeability transition pore opening in response to oxidative stress in vitro

  Zervou S. et al, (2010), CARDIOVASCULAR RESEARCH, 87, S126 - S126

• c-Myc directly induces both impaired insulin secretion and loss of β-cell mass, independently of hyperglycemia in vivo.

  Cheung L. et al, (2010), Islets, 2, 37 - 45

• c-Myc directly induces both impaired insulin secretion and loss of β-cell mass, independently of hyperglycemia in vivo.

  Cheung L. et al, (2010), Islets, 2, 37 - 45

• Regulators of G protein signalling proteins in the human myometrium.

  Ladds G. et al, (2009), Eur J Pharmacol, 610, 23 - 28

• Association of the 894G>T polymorphism in the endothelial nitric oxide synthase gene with risk of acute myocardial infarction.

  Andrikopoulos GK. et al, (2008), BMC Med Genet, 9

• Association of the 894G>T polymorphism in the endothelial nitric oxide synthase gene with risk of acute myocardial infarction

  Andrikopoulos GK. et al, (2007), BMC Medical Genetics, 9

• Role of hyperglycaemia in pathogenesis of diabetic cardiovascular disease

  Zervou S. and Khan M., (2007), Vascular Disease Prevention, 4, 125 - 139

• Progesterone signaling in human myometrium through two novel membrane G protein-coupled receptors: potential role in functional progesterone withdrawal at term.

  Karteris E. et al, (2006), Mol Endocrinol, 20, 1519 - 1534

• Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines.

  Chen J. et al, (2006), Diabetologia, 49, 1292 - 1302

• Food deprivation differentially modulates orexin receptor expression and signaling in rat hypothalamus and adrenal cortex

  Karteris E. et al, (2005), American Journal of Physiology - Endocrinology and Metabolism, 288

• Food deprivation differentially modulates orexin receptor expression and signaling in rat hypothalamus and adrenal cortex.

  Karteris E. et al, (2005), Am J Physiol Endocrinol Metab, 288, E1089 - E1100

• Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis.

  Pelengaris S. et al, (2004), BMC Biol, 2

• Promoter analysis of human corticotropin-releasing factor (CRF) type 1 receptor and regulation by CRF and urocortin.

  Parham KL. et al, (2004), Endocrinology, 145, 3971 - 3983

• 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004.

  Veitenhansl M. et al, (2004), Diabetologia, 47, A1 - A464

• The Glu298→Asp polymorphism of the endothelial nitric oxide synthase gene is associated with endometriosis Presented at the First Panhellenic Congress on Endometriosis, which was held in Heraklion, Greece, on November 22 and 23, 2002

  Zervou S. et al, (2003), Fertility and Sterility, 80, 1524 - 1525

• The Glu298-->Asp polymorphism of the endothelial nitric oxide synthase gene is associated with endometriosis.

  Zervou S. et al, (2003), Fertil Steril, 80, 1524 - 1525

• Steroids mediate the expression of cytoplasmic and membrane-linked components in human myometrial cells.

  Zervou S. et al, (2002), Mol Hum Reprod, 8, 597 - 605

• Prostaglandins and prostanoid receptors in human pregnancy and parturition.

  Slater DM. et al, (2002), J Soc Gynecol Investig, 9, 118 - 124

• Nitric oxide synthase expression and steroid regulation in the uterus of women with menorrhagia.

  Zervou S. et al, (1999), Mol Hum Reprod, 5, 1048 - 1054

• Augmentation of Creatine in the Heart.

  Zervou S. et al, Mini Rev Med Chem, 16, 19 - 28

Recent Publications

• AUGMENTATION OF CREATINE KINASE IN VITRO PROTECTS AGAINST SIMULATED ISCHAEMIA REPERFUSION INJURY

  Zervou S. et al, (2017), HEART, 103, A144 - A144

• Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure.

  Atzler D. et al, (2017), Circulation, 135, 400 - 402

• Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro.

  Zervou S. et al, (2017), PLoS One, 12

• Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms.

  Zervou S. et al, (2016), Amino Acids, 48, 1969 - 1981

• Augmentation of Creatine in the Heart.

  Zervou S. et al, (2016), Mini Rev Med Chem, 16, 19 - 28