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Janina Nahler

BSc (Hons) Biological Sciences (Immunology)

DPhil Student

I am a DPhil student working under the supervision of Prof Graham Ogg. My research focuses on human group 2 Innate Lymphoid Cells (ILC2s) that have emerged as cells bridging the innate and adaptive arms of the immune system.

Initially discovered in the context of helminth infection, it has become evident that ILC2s play diverse roles by exhibiting both pro- and anti-inflammatory functions. Deciphering the mechanisms that regulate human ILC2 activity has been of interest to this lab for several years, especially because dysregulated ILC2 responses have been associated with allergic inflammatory disorders including atopic dermatitis. By isolating ILC2s from human blood and skin and performing functional in vitro assays (FACS, qRT-PCR, ELISA, etc), I aim to elucidate how they can sense and respond to cues from their microenvironment and influence surrounding immune cells. It is believed that ILC2s act as initiators of allergic immune responses, therefore knowing ILC2- activating and -inhibitory signals might allow the development of novel therapeutic strategies.

2012-2016: University of Edinburgh, BSc (Hons) Biological Sciences (Immunology);
May-July 2015: Wellcome Trust Biomedical Vacation Scholarship, Prof Rick Maizels (University of Edinburgh);
May-July 2014: summer student, Rappsilber laboratory, Prof Juri Rappsilber (University of Edinburgh);
2004-2012: Wiedner Gymnasium Sir Karl Popper Schule (Vienna).