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Deborah Gill

PhD, BSc (Hons)

Professor of Gene Medicine

As Co-Director of the Gene Medicine Research Group, my research is focused on developing new genetic therapies for lung diseases.

I am a Principal Investigator within the UK Gene Therapy Consortium which has been at the forefront of gene therapy for Cystic Fibrosis (CF) for over 20 years. The Consortium completed the world's largest gene therapy clinical trial in CF patients, delivering an aerosol gene therapy at monthly intervals in a study over a 12 month period.

The success of both gene therapy, which introduces genes to cells, and gene editing, which can correct genetic mutations, depend on efficient delivery of genetic material to cells. Therefore, much of my work has been focused on developing delivery vectors, both non-viral, plasmid-based, and Lentiviral and AAV vectors for successful translation of these new therapies to the clinic.

In addition to targeting lung diseases we are evaluating whether the airways can be used as a ‘protein factory’ to make therapeutic protein. A single dose of an efficient gene transfer vector could replace multiple injections and reduce treatment costs.

I have supervised many D.Phil and Masters students to completion of their post-graduate degrees and as Director of Graduate Studies for the Radcliffe Department of Medicine (RDM) I am involved in many aspects of graduate student mentoring and training. I am also Chair of the Graduate School Committee for the Medical Sciences Division at Oxford.

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Selected Publications


Recent Publications

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