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Contact information

Email
hanan.lamlum@cardiov.ox.ac.uk

Hanan Lamlum

DPhil, BSc (Hons)

Head of Clinical Research Operations and Governance

Key publications

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients.

Crabtree M. et al, (2003), Oncogene, 22, 4257 - 4265

Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC.

Sieber OM. et al, (2002), Proc Natl Acad Sci U S A, 99, 16910 - 16915

Mutation cluster region, association between germline and somatic mutations and genotype-phenotype correlation in upper gastrointestinal familial adenomatous polyposis.

Groves C. et al, (2002), Am J Pathol, 160, 2055 - 2061

Germline APC variants in patients with multiple colorectal adenomas, with evidence for the particular importance of E1317Q.

Lamlum H. et al, (2000), Hum Mol Genet, 9, 2215 - 2221

APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits".

Rowan AJ. et al, (2000), Proc Natl Acad Sci U S A, 97, 3352 - 3357

APC mutations are sufficient for the growth of early colorectal adenomas.

Lamlum H. et al, (2000), Proc Natl Acad Sci U S A, 97, 2225 - 2228

Recent publications

Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer.

Bendardaf R. et al, (2008), Oncol Rep, 20, 999 - 1004

Thymidylate synthase and microsatellite instability in colorectal cancer: implications for disease free survival, treatment response and survival with metastases.

Bendardaf R. et al, (2008), Acta Oncol, 47, 1046 - 1053

Thymidylate synthase expression in primary colorectal tumours is correlated with its expression in metastases.

Bendardaf R. et al, (2007), Scand J Gastroenterol, 42, 471 - 476

Mismatch repair status is a predictive factor of tumour response to 5-fluorouracil and irinotecan chemotherapy in patients with advanced colorectal cancer.

Bendardaf R. et al, (2007), Tumour Biol, 28, 212 - 220

Comparison of CD44 expression in primary tumours and metastases of colorectal cancer.

Bendardaf R. et al, (2006), Oncol Rep, 16, 741 - 746

E-cadherin expression pattern in primary colorectal carcinomas and their metastases reflects disease outcome.

Elzagheid A. et al, (2006), World J Gastroenterol, 12, 4304 - 4309

Thymidylate synthase expression levels: a prognostic and predictive role in advanced colorectal cancer.

Bendardaf R. et al, (2005), Oncol Rep, 14, 657 - 662

E-cadherin, CD44s and CD44v6 correlate with tumour differentiation in colorectal cancer.

Bendardaf R. et al, (2005), Oncol Rep, 13, 831 - 835

Nuclear area is a prognostic determinant in advanced colorectal cancer.

Buhmeida A. et al, (2005), Anticancer Res, 25, 3083 - 3088

Prognostic and predictive molecular markers in colorectal carcinoma.

Bendardaf R. et al, (2004), Anticancer Res, 24, 2519 - 2530

More publications