Contact information
Hanan Lamlum
DPhil, BSc (Hons)
Head of Clinical Research Operations and Governance
Key publications
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APC mutations are sufficient for the growth of early colorectal adenomas.
Lamlum H. et al, (2000), Proc Natl Acad Sci U S A, 97, 2225 - 2228
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Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC.
Sieber OM. et al, (2002), Proc Natl Acad Sci U S A, 99, 16910 - 16915
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APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits".
Rowan AJ. et al, (2000), Proc Natl Acad Sci U S A, 97, 3352 - 3357
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Germline APC variants in patients with multiple colorectal adenomas, with evidence for the particular importance of E1317Q.
Lamlum H. et al, (2000), Hum Mol Genet, 9, 2215 - 2221
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Mutation cluster region, association between germline and somatic mutations and genotype-phenotype correlation in upper gastrointestinal familial adenomatous polyposis.
Groves C. et al, (2002), Am J Pathol, 160, 2055 - 2061
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Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients.
Crabtree M. et al, (2003), Oncogene, 22, 4257 - 4265
Recent publications
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Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer.
Bendardaf R. et al, (2008), Oncol Rep, 20, 999 - 1004
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Thymidylate synthase and microsatellite instability in colorectal cancer: implications for disease free survival, treatment response and survival with metastases.
Bendardaf R. et al, (2008), Acta Oncol, 47, 1046 - 1053
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Thymidylate synthase expression in primary colorectal tumours is correlated with its expression in metastases.
Bendardaf R. et al, (2007), Scand J Gastroenterol, 42, 471 - 476
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Mismatch repair status is a predictive factor of tumour response to 5-fluorouracil and irinotecan chemotherapy in patients with advanced colorectal cancer.
Bendardaf R. et al, (2007), Tumour Biol, 28, 212 - 220
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Comparison of CD44 expression in primary tumours and metastases of colorectal cancer.
Bendardaf R. et al, (2006), Oncol Rep, 16, 741 - 746
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E-cadherin expression pattern in primary colorectal carcinomas and their metastases reflects disease outcome.
Elzagheid A. et al, (2006), World J Gastroenterol, 12, 4304 - 4309
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Thymidylate synthase expression levels: a prognostic and predictive role in advanced colorectal cancer.
Bendardaf R. et al, (2005), Oncol Rep, 14, 657 - 662
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Nuclear area is a prognostic determinant in advanced colorectal cancer.
Buhmeida A. et al, (2005), Anticancer Res, 25, 3083 - 3088
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E-cadherin, CD44s and CD44v6 correlate with tumour differentiation in colorectal cancer.
Bendardaf R. et al, (2005), Oncol Rep, 13, 831 - 835
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Prognostic and predictive molecular markers in colorectal carcinoma.
Bendardaf R. et al, (2004), Anticancer Res, 24, 2519 - 2530