Research groups
Websites
-
Snelling Group
Soft Tissue Repair
- Human Cell Atlas project
-
Chan Zuckerberg Initiative
An Ancestrally Inclusive Atlas of Healthy Musculoskeletal Tissues
Carla Cohen
Computational Biologist
- Analysis of single-cell RNA-seq data from musculoskeletal tissues
- Trainer in computational biology
Delivering an ethnically diverse cell atlas of human musculoskeletal tissue
I am a computational biologist working in David Sims' Computational Biology group at the WIMM and in Sarah Snelling’s Soft Tissue Repair group at the Botnar Research Centre.
I work on the Human Cell Atlas project, a global consortium which aims to map all cells in the healthy human body. I analyse single-nuclear RNA-seq data from musculoskeletal tissues including tendon, muscle, bone and capsule to create an ethnically diverse atlas of healthy cells in the adult joint. This work will produce an open-source comprehensive resource for researchers around the world and will provide a foundation for further studies on human disease.
I am also a trainer in computational methods including Linux, R programming and core/advanced methods in single-cell RNA-seq analysis using R and Python, in collaboration with the African Institute of Biomedical Science and Technology in Harare, Zimbabwe.
My work is funded from the Chan-Zuckerberg Initiative and fits within their ambitious goal to solve human disease by 2100.
I completed my DPhil in the Dunn School of Pathology with William James, and went on to a postdoctoral position with Dixie Mager in the Terry Fox Laboratory, Vancouver, Canada. From 2011-2022 I worked in the University of Oxford with Paul Wordsworth and Julian Knight on the genetics and epigenetics of ankylosing spondylitis, an inflammatory arthritis. I took a career break from 2013-2017 when I had young children, and received funding from the University’s Returning Carer’s Fund when I returned to work. I am a keen supporter of public engagement with science, and improving equality, diversity and inclusion in science.
Recent publications
-
INVESTIGATING THE ANKYLOSING SPONDYLITIS-ASSOCIATED REGULATORY SNPS AT THE RUNX3 LOCUS WITH A FUNCTIONAL GENOMICS APPROACH
Conference paper
Vecellio M. et al, (2021), ANNALS OF THE RHEUMATIC DISEASES, 80, 411 - 411
-
COMPREHENSIVE EPIGENOMIC PROFILING REVEALS DISEASE-SPECIFIC CHROMATIN STATES IN ANKYLOSING SPONDYLITIS
Conference paper
Cohen CJ. et al, (2021), CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 39, 1155 - 1155
-
INVESTIGATING THE REGULATORY SNPS AT THE RUNX3 LOCUS ASSOCIATED WITH ANKYLOSING SPONDYLITIS
Conference paper
Vecellio ML. et al, (2018), ANNALS OF THE RHEUMATIC DISEASES, 77, 158 - 158
-
EXPLORING THE ANKYLOSING SPONDYLITIS-ASSOCIATED REGULATORY SNPs AT THE RUNX3 LOCUS
Conference paper
Vecellio M. et al, (2018), CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 36, 734 - 734
-
RUNX3 and T-Bet in Immunopathogenesis of Ankylosing Spondylitis-Novel Targets for Therapy?
Journal article
Vecellio M. et al, (2018), Front Immunol, 9