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We are a computational biology research group using genomic and functional genomic data to study transcriptional regulation in neuroscience.

The human brain is one of the most complex organs in nature containing 100 billion cells and trillions of connections, all derived from a single fertilised egg. Our research group uses computational genomics approaches to study the transcriptional programmes that give rise to different brain structures and functions in a range of model organisms.

Working with Scott Waddell and Stephen Goodwin at the Centre for Neural Circuits and Behaviour (CNCB) we are using single cell sequencing and machine learning approaches to study the diversity of neurons in the brain of the fruit fly. As the fly midbrain contains only 40,000 cells modern sequencing approach can generate transcriptional data at a whole brain scale. Using these methods we are investigating the effects of thirst, hunger and learning and memory on different clusters of neurons within the brain.

We are also developing a novel lineage tracing method, Lineage-seq, to track the development of neurons within the mouse brain in collaboration with Colin Ackerman at the department of Pharmacology. This method will enable us to see for the first time the different cell types generated from different neuronal progenitor cells.

Our team

Selected publications

Collaborators

Scott Waddell (CNCB)

Stephen Goodwin (CNCB)

Gero Miesenboeck (CNCB)

Alison Simmons (MRC WIMM)

Richard Cornall (MRC WIMM/WTCHG)

Colin Ackerman (Pharmacology)

Rob Klose (Biochemistry)

Lab Alumni

Nick Ilott

Steve Sansom

Helen Knight

Ian Sudbery

Jethro Johnson

Antonio Berlanga

Mike Morgan

Tom Smith

Katy Brown

Adam Cribbs

Kath Fawcett Hania Pavlou 
Martin Dienstbier Sebastian Luna Valero
Andreas Heger



Related research themes