Contact information
Research groups
Alessandro Cavallo
Postdoctoral Research Scientist
My research focusses on the transcriptional regulation of endothelial-to-haematopoietic transition, the developmental process by which haematopoietic stem cells are formed in the embryo. I am modelling this process "in a dish", by differentiating human induced pluripotent stem cells (iPSCs) in vitro. To identify the key factors which are important for generating blood and immune cells in vitro, I am using single cell multi-omic and other epigenetic profiling approaches, as well as gene regulatory network analysis. Future potential applications of my research include blood (stem) cell generation for regenerative medicine and cell therapy applications.
Prior to my current position, I completed a DPhil here at Oxford in Prof. Marella de Bruijn's group.
Recent publications
-
Evolutionary conservation and divergence of the transcriptional regulation of bivalve shell secretion across life-history stages
Journal article
Cavallo A. et al, (2022), Royal Society Open Science, 9
-
Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development.
Journal article
Owens DDG. et al, (2022), Nat Commun, 13
-
Lipid storage patterns in marine copepods: environmental, ecological, and intrinsic drivers
Journal article
Cavallo A. and Peck LS., (2020), ICES Journal of Marine Science, 77, 1589 - 1601
-
Molecular mechanisms underpinning transgenerational plasticity in the green sea urchin Psammechinus miliaris
Journal article
Clark MS. et al, (2019), SCIENTIFIC REPORTS, 9