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CLINICAL QUESTION: Is transfusing red cell components using a restrictive transfusion threshold (Hb < 75 g L-1 ) as safe as a liberal transfusion threshold (Hb < 95 g L-1 in intensive care and < 85 g L-1 outside intensive care) during and after cardiac surgery for adults at moderate to high risk of death? EVIDENCE FROM TRIAL: In adults undergoing cardiac surgery who were at moderate to high risk for death, using a restrictive red-cell transfusion threshold was as safe as a liberal red cell transfusion threshold (composite outcome of death from any cause, myocardial infarction, stroke or new-onset renal failure with dialysis at 6 months after surgery).

Original publication




Journal article


Transfus Med

Publication Date





77 - 79


cardiac surgery, randomised-controlled trial, red cell transfusions, Aged, Cardiac Surgical Procedures, Critical Care, Erythrocyte Transfusion, Female, Follow-Up Studies, Humans, Male, Middle Aged, Platelet Transfusion