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The cell division genes ftsY, ftsE and ftsX form an operon mapping at 76 min on the Escherichia coli chromosome. The protein products of these genes have been identified previously. We have studied the cellular location of the radiolabelled Fts proteins using maxicells and standard fractionation procedures. Previous protein sequence homologies suggested an inner membrane location for FtsE. We have confirmed this predicted location and have shown that FtsY and FtsX are also inner membrane-associated. These results are in agreement with the hypothesis that FtsE may act at the inner membrane, in a "septalsome" complex, by coupling ATP hydrolysis to the process of bacterial cell division.

Original publication




Journal article


Mol Gen Genet

Publication Date





504 - 508


Bacterial Proteins, Cell Compartmentation, Cell Division, Cell Fractionation, Cell Membrane, Escherichia coli, Genes, Bacterial, Magnesium, Molecular Weight