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Two independent approaches have provided an assignment for the factor IX (Haemophilia B) locus to Xq26-qter, the distal region of the X chromosome long arm. Cloned DNA sequences of the gene were hybridized to restriction enzyme digests of DNA prepared from a series of somatic cell hybrids containing different X-chromosomal regions and also in situ to prepared metaphase chromosomes.


Journal article


Ann Hum Genet

Publication Date





145 - 152


Animals, Cell Line, Chromosome Deletion, Chromosome Mapping, DNA, DNA Restriction Enzymes, Factor IX, Female, Humans, Mice, Nucleic Acid Hybridization, Plasmids, X Chromosome