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Transmissible chromosomal instability, characterized by non-clonal cytogenetic aberrations with a high frequency of chromatid-type aberrations together with a lower frequency of chromosome-type aberrations, has been demonstrated in the clonal descendants of human haemopoietic stem cells after alpha- but not X-irradiation. Comparable cytogenetic abnormalities have also been demonstrated in non-clonal cultures of alpha-irradiated primary human bone marrow, but a different pattern of delayed aberrations, mainly of chromosome-type, was found after X-irradiation in non-clonal cultures. In clonal analyses, delayed apoptotic cell death was evident after both X- and alpha-irradiation. It is suggested that the type of radiation exposure, the type of cell and its genetically determined susceptibility are factors that may influence the expression of delayed effects of radiation.


Journal article


Int J Radiat Biol

Publication Date





287 - 293


Alpha Particles, Apoptosis, Bone Marrow, Bone Marrow Cells, Cells, Cultured, Chromatids, Chromosome Aberrations, Clone Cells, Colony-Forming Units Assay, Hematopoietic Stem Cells, Humans, X-Rays