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Here we identify hundreds of RNA G-quadruplex (rG4) candidates in microRNAs (miRNAs), characterize the miRNA structure and miRNA-mRNA interactions on several mammalian-conserved miRNAs, and reveal the formation of rG4s in miRNAs. Notably, we study the effect of these rG4s in cells and uncover the role of rG4s in miRNA-mediated post-transcriptional regulation.

Original publication

DOI

10.1039/c8cc04635b

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

25/09/2018

Volume

54

Pages

10878 - 10881

Keywords

G-Quadruplexes, HEK293 Cells, Humans, MicroRNAs