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A device for collecting and holding a small metered sample of blood or other liquid comprises a length of open-ended capillary tube (17) supported in a holder (18), and a bottle (10) sealed at sub-atmospheric internal pressure by a flexible membrane (15) extends across the lower end of a tubular invagination (12) in the top wall (13) of the bottle. The capillaryry tube and holder are slidably lowered in the invagination, above the membrane (15), and project upwardly. A threaded cap (20) is screwed onto a neck (11) of the bottle and has a shoulder (23) which when the cap is screwed fully down on the neck, bears on the upper end of the holder (18) and depresses this causing the capillary tube to pierce the membrane so that a blood sample previously drawn into the tube (17) by capillary action will be drawn into the interior of the bottle by suction. A spacer device (22 or 50) removably interposed between the cap (20) and the bottle (10) prevents the inadvertent depression of the tube and holder by the cap. The device can be used to draw a metered blood sample into the capillary tube from a patient's blood spot by capillary action and then to transfer the sample by suction into the bottle by causing the capillary tube to pierce the membrane, which will then seal around the tube circumference to prevent the ingress of air.


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