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Both CC and CXC-class chemokines drive inflammatory disease. Tick salivary chemokine-binding proteins (CKBPs), or evasins, specifically bind subsets of CC- or CXC-chemokines, and could precisely target disease-relevant chemokines. Here we have used yeast surface display to identify two tick evasins: a CC-CKBP, P1243 from Amblyomma americanum and a CXC-CKBP, P1156 from Ixodes ricinus. P1243 binds 11 CC-chemokines with Kd 

Original publication

DOI

10.1038/s41598-018-24568-9

Type

Journal article

Journal

Sci Rep

Publication Date

20/04/2018

Volume

8

Keywords

Amino Acid Sequence, Animals, Arachnida, Chemokines, Chemokines, CC, Chemokines, CXC, Genetic Engineering, HEK293 Cells, Humans, Protein Binding, Receptors, CXCR, Receptors, Chemokine, Saccharomyces cerevisiae, THP-1 Cells, Ticks