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The combination of next-generation sequencing technologies and high-throughput genotyping platforms has revolutionized the pursuit of genetic variants that contribute towards disease. Furthermore, these technologies have provided invaluable insight into the genetic factors that prevent individuals from developing disease. Exploiting the evolutionary mechanisms that were designed by nature to help prevent disease is an attractive line of enquiry. Such efforts have the potential to generate a therapeutic target roadmap and rejuvenate the current drug-discovery pathway. By delineating the genomic factors that are protective against disease, there is potential to derive highly effective, genomically anchored medicines that assist in maintaining health.

Original publication

DOI

10.1038/nrg4017

Type

Journal article

Journal

Nat Rev Genet

Publication Date

12/2015

Volume

16

Pages

689 - 701

Keywords

Alleles, Drug Discovery, Genetic Predisposition to Disease, Genetic Variation, High-Throughput Nucleotide Sequencing, Humans