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© 2014 Elsevier Inc. All rights reserved. Plasma continues to be commonly transfused, both prophylactically to prevent bleeding in critically ill patients perceived to be at higher risk of bleeding and therapeutically to treat bleeding in patients with uncontrolled bleeding. For both indications, the main rationale is to replace or supplement deficiencies or depleted levels of prohemostatic coagulation factors. What is often not appreciated by cLinicians is the variabiLity between plasma collections for transfusion, nor the impact of collection and processing and storage on levels of coagulant factors.

Original publication





Book title

Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms

Publication Date



3166 - 3170