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Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Valpha24/Vbeta11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike Valpha24/Vbeta11 NKT cells found in blood, those in the liver appeared to be recently activated.

Type

Journal article

Journal

J Virol

Publication Date

02/2003

Volume

77

Pages

2251 - 2257

Keywords

Antigens, CD, Antigens, CD3, Antigens, CD56, Antigens, Differentiation, T-Lymphocyte, Hepatitis C, Humans, Immunophenotyping, Killer Cells, Natural, Lectins, C-Type, Lymphocyte Activation, Receptors, Antigen, T-Cell, alpha-beta, T-Lymphocyte Subsets