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BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with coronary microvascular dysfunction in the absence of obstructive coronary artery disease (CAD). Cardiovascular magnetic resonance (CMR) T1-mapping at rest and during adenosine stress can assess coronary vascular reactivity. We hypothesised that the non-contrast T1 response to vasodilator stress will be altered in patients with T2DM without CAD compared to controls due to coronary microvascular dysfunction. METHODS: Thirty-one patients with T2DM and sixteen matched healthy controls underwent CMR (3 T) for cine, rest and adenosine stress non-contrast T1-mapping (ShMOLLI), first-pass perfusion and late gadolinium enhancement (LGE) imaging. Significant CAD (>50% coronary luminal stenosis) was excluded in all patients by coronary computed tomographic angiography. RESULTS: All subjects had normal left ventricular (LV) ejection and LV mass index, with no LGE. Myocardial perfusion reserve index (MPRI) was lower in T2DM than in controls (1.60 ± 0.44 vs 2.01 ± 0.42; p = 0.008). There was no difference in rest native T1 values (p = 0.59). During adenosine stress, T1 values increased significantly in both T2DM patients (from 1196 ± 32 ms to 1244 ± 44 ms, p 

Original publication




Journal article


J Cardiovasc Magn Reson

Publication Date





Cardiovascular magnetic resonance, Diabetes mellitus, Microvascular obstruction, Myocardial perfusion, ShMOLLI T1-mapping, Adenosine, Adult, Case-Control Studies, Contrast Media, Coronary Artery Disease, Coronary Circulation, Coronary Vessels, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Early Diagnosis, Female, Humans, Magnetic Resonance Imaging, Cine, Male, Meglumine, Microcirculation, Middle Aged, Myocardial Perfusion Imaging, Observer Variation, Organometallic Compounds, Predictive Value of Tests, Reproducibility of Results, Stroke Volume, Vasodilator Agents, Ventricular Function, Left