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The gene for Huntington disease, a neurodegenerative disorder with autosomal dominant inheritance, has been localized to the terminal portion of the short arm of human chromosome 4 (4p16.3) by linkage analysis. Since eventual isolation of the gene requires the application of high-resolution genetic analysis coupled with long-range DNA mapping and cloning techniques, we have constructed a physical map of the chromosomal region 4p16.3 using more than 20 independently derived probes. We have grouped these markers into three clusters which have been ordered and oriented by genetic and somatic cell genetic mapping information. The mapped region extends from D4S10 (G8) toward the telomere and covers minimally 5 Mb.

Type

Journal article

Journal

Genomics

Publication Date

01/1990

Volume

6

Pages

1 - 15

Keywords

Chromosome Mapping, Chromosomes, Human, Pair 4, DNA Probes, Electrophoresis, Agar Gel, Gene Library, Genetic Linkage, Humans, Huntington Disease