Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.
Tanskanen T., van den Berg L., Välimäki N., Aavikko M., Ness-Jensen E., Hveem K., Wettergren Y., Bexe Lindskog E., Tõnisson N., Metspalu A., Silander K., Orlando G., Law PJ., Tuupanen S., Gylfe AE., Hänninen UA., Cajuso T., Kondelin J., Sarin A-P., Pukkala E., Jousilahti P., Salomaa V., Ripatti S., Palotie A., Järvinen H., Renkonen-Sinisalo L., Lepistö A., Böhm J., Mecklin J-P., Al-Tassan NA., Palles C., Martin L., Barclay E., Tenesa A., Farrington SM., Timofeeva MN., Meyer BF., Wakil SM., Campbell H., Smith CG., Idziaszczyk S., Maughan TS., Kaplan R., Kerr R., Kerr D., Buchanan DD., Win AK., Hopper J., Jenkins MA., Newcomb PA., Gallinger S., Conti D., Schumacher FR., Casey G., Cheadle JP., Dunlop MG., Tomlinson IP., Houlston RS., Palin K., Aaltonen LA.
Genome-wide association studies have been successful in elucidating the genetic basis of colorectal cancer (CRC), but there remains unexplained variability in genetic risk. To identify new risk variants and to confirm reported associations, we conducted a genome-wide association study in 1,701 CRC cases and 14,082 cancer-free controls from the Finnish population. A total of 9,068,015 genetic variants were imputed and tested, and 30 promising variants were studied in additional 11,647 cases and 12,356 controls of European ancestry. The previously reported association between the single-nucleotide polymorphism (SNP) rs992157 (2q35) and CRC was independently replicated (p = 2.08 × 10-4 ; OR, 1.14; 95% CI, 1.06-1.23), and it was genome-wide significant in combined analysis (p = 1.50 × 10-9 ; OR, 1.12; 95% CI, 1.08-1.16). Variants at 2q35, 6p21.2, 8q23.3, 8q24.21, 10q22.3, 10q24.2, 11q13.4, 11q23.1, 14q22.2, 15q13.3, 18q21.1, 20p12.3 and 20q13.33 were associated with CRC in the Finnish population (false discovery rate < 0.1), but new risk loci were not found. These results replicate the effects of multiple loci on the risk of CRC and identify shared risk alleles between the Finnish population isolate and outbred populations.