Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Ten monoclonal antibodies (mAbs), that comprised temporary cluster TC1, and included a previously published CD45R mAb, were compared together with mAb IL-A116 which did not cluster with any workshop mAb. The ten mAbs of TC1 immunoprecipitate molecules with an M(r) of 220 and 205 kDa; sequential precipitation with a CD45 mAb indicates that these mAbs recognize restricted isoforms of the leukocyte common antigen. Cellular and tissue distribution suggests that mAbs within TC1 recognize at least two different specificities of the CD45 family of molecules. mAb IL-A116 precipitated a molecule of 180 kDa suggesting that it may recognize the CD45RO isoform of the leukocyte common antigen.

Type

Journal article

Journal

Vet Immunol Immunopathol

Publication Date

11/1993

Volume

39

Pages

129 - 136

Keywords

Animals, Antibodies, Monoclonal, Antibody Specificity, Cattle, Electrophoresis, Polyacrylamide Gel, Flow Cytometry, Immunoenzyme Techniques, Leukocyte Common Antigens, Leukocytes, Precipitin Tests