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We have estimated the half-life of serum growth hormone (GH) in six subjects on 14 occasions following an intravenous bolus injection of either 50 or 500 mU of biosynthetic human growth hormone (B-hGH) while endogenous GH secretion was suppressed by a continuous infusion of somatostatin. The disappearance curve of serum GH was mono-exponential and the mean half-life was 8.9 min (SD 1.5). This is less than previously reported and has important implications for the performance of GH profiles, which should be performed with 10-15 min sampling intervals, and the calculation of pituitary GH secretion rates.

Original publication




Journal article


Clin Endocrinol (Oxf)

Publication Date





443 - 450


Adolescent, Adult, Enzyme-Linked Immunosorbent Assay, Growth Hormone, Half-Life, Humans, Immunoradiometric Assay, Male, Middle Aged, Recombinant Proteins, Somatostatin