Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

We have estimated the half-life of serum growth hormone (GH) in six subjects on 14 occasions following an intravenous bolus injection of either 50 or 500 mU of biosynthetic human growth hormone (B-hGH) while endogenous GH secretion was suppressed by a continuous infusion of somatostatin. The disappearance curve of serum GH was mono-exponential and the mean half-life was 8.9 min (SD 1.5). This is less than previously reported and has important implications for the performance of GH profiles, which should be performed with 10-15 min sampling intervals, and the calculation of pituitary GH secretion rates.

Original publication

DOI

10.1111/j.1365-2265.1989.tb00444.x

Type

Journal article

Journal

Clin Endocrinol (Oxf)

Publication Date

04/1989

Volume

30

Pages

443 - 450

Keywords

Adolescent, Adult, Enzyme-Linked Immunosorbent Assay, Growth Hormone, Half-Life, Humans, Immunoradiometric Assay, Male, Middle Aged, Recombinant Proteins, Somatostatin