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The effect of intravenous infusion of islet amyloid polypeptide (IAPP/amylin) and calcitonin gene-related peptide (CGRP) on blood glucose and plasma insulin in the basal and glucose-stimulated state was investigated in the anaesthetized rat. Both peptides had no effect on basal blood glucose or plasma insulin but following an intravenous bolus of glucose, CGRP-treated rats were hyperglycaemic and hyperinsulinaemic compared with control animals which were similar to IAPP-treated rats. IAPP had no effect on glucose-stimulated islet insulin secretion. These results suggest that CGRP, but not IAPP, alters glucose removal in vivo.

Original publication

DOI

10.1007/BF01117233

Type

Journal article

Journal

Biosci Rep

Publication Date

08/1990

Volume

10

Pages

339 - 345

Keywords

Amyloid, Animals, Blood Glucose, Calcitonin Gene-Related Peptide, Injections, Intravenous, Insulin, Islet Amyloid Polypeptide, Islets of Langerhans, Male, Rats, Rats, Inbred Strains