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There are a number of autoimmune subepidermal blistering disorders in which the presence of autoantibodies has been well documented. These include pemphigoid gestationis, linear immunoglobulin A disease, bullous pemphigoid, lichen planus pemphigoides and mucous membrane pemphigoid. The antibodies involved in these diseases are commonly directed against protein components of the basement membrane zone. The requirement for T cells in the production of autoantibodies, the infiltration of T cells into lesions and HLA-associations have led to a number of investigations into the role of T cells in these diseases. This review will concentrate on the evidence for the role of T cells in the pathogenesis of mucous membrane pemphigoid. © 2006, Future Drugs Ltd. All rights reserved.

Original publication

DOI

10.1586/17469872.1.1.25

Type

Journal article

Journal

Expert Review of Dermatology

Publication Date

01/02/2006

Volume

1

Pages

25 - 30