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How cells integrate antagonistic receptor signaling events is enigmatic. Using superresolution optical microscopy, Lopes et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608094) demonstrate the nanometer-scale molecular reorganization of antagonistic signaling receptors in macrophages, after engagement by the receptors of activating and inhibitory ligands. They propose that large-scale rearrangements of this type underpin decision-making by these cells.

Original publication

DOI

10.1083/jcb.201702028

Type

Journal article

Journal

J Cell Biol

Publication Date

03/04/2017

Volume

216

Pages

871 - 873

Keywords

Humans, Ligands, Macrophages, Receptors, Cell Surface, Signal Transduction