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Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-therapy-naive, HIV-1-infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were substantially more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers that are predictive of progression.

Original publication

DOI

10.1038/nm.4161

Type

Journal article

Journal

Nat Med

Publication Date

10/2016

Volume

22

Pages

1090 - 1093

Keywords

Adult, Coinfection, Disease Progression, Female, Fluorodeoxyglucose F18, HIV Infections, Humans, Interferon-gamma Release Tests, Latent Tuberculosis, Male, Mycobacterium tuberculosis, Positron Emission Tomography Computed Tomography, Radiography, Thoracic, Radiopharmaceuticals, South Africa, Sputum, Tuberculosis, Tuberculosis, Pulmonary