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The 'seed and soil' hypothesis for metastasis sets forth the concept that a conducive microenvironment, or niche, is required for disseminating tumour cells to engraft distant sites. This Opinion presents emerging data that support this concept and outlines the potential mechanism and temporal sequence by which changes occur in tissues distant from the primary tumour. To enable improvements in the prognosis of advanced malignancy, early interventions that target both the disseminating seed and the metastatic soil are likely to be required.

Original publication

DOI

10.1038/nrc2621

Type

Journal article

Journal

Nat Rev Cancer

Volume

9

Pages

285 - 293

Keywords

Bone Marrow Cells, Humans, Models, Biological, Neoplasm Metastasis, Neoplasms