Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The generation by genetic engineering of two murine models to investigate atherosclerosis, such as the apoE- and LDLr- deficient mice, is providing an extraordinaire knowledge of the effect of different nutrients on this complex disease. The present revision provides a comprehensive overview of the advances in this field that point to a remarkable complexity. While some controversies over puzzling results could be explained invoking potential nutrient interactions or different food sources of nutrients, it also appears that other factors such as sex, genetic background or immunological status are emerging as generators of differential responses to nutrients during the atherosclerotic process.

Type

Journal article

Journal

Front Biosci

Publication Date

01/01/2006

Volume

11

Pages

955 - 967

Keywords

Alcohol Drinking, Allergy and Immunology, Animals, Antioxidants, Apolipoproteins E, Arginine, Arteriosclerosis, Ascorbic Acid, Atherosclerosis, Cell Proliferation, Dietary Fats, Disease Models, Animal, Energy Metabolism, Fatty Acids, Monounsaturated, Fatty Acids, Unsaturated, Genetic Engineering, Genetic Variation, Genomics, Homocysteine, Insulin Resistance, Iron, Magnesium, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Biological, Models, Genetic, Phytosterols, Receptors, LDL, Sex Factors, Sodium, Taurine, Vitamin E