Restriction mapping of a new deletion responsible for G gamma (delta beta)o thalassemia.
Jones RW., Old JM., Trent RJ., Clegg JB., Weatherall DJ.
DNA from individuals heterozygous for (G)gamma(deltabeta)(o) thalassaemia has been studied by restriction endonuclease analysis. The results reveal a new molecular defect associated with this condition. A total of three defects is now responsible for the one single phenotype, thereby emphasising the complex relationship between genotype and phenotype among the disorders of beta-like globin synthesis in man.