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MicroRNAs (miRNAs) are tiny non-coding RNA molecules that regulate gene expression predominantly at the post-transcriptional level. Far from being simple intracellular regulators, miRNAs have recently been involved in intercellular communication and have been shown to circulate in the bloodstream in stable forms. In the past years specific miRNA expression patterns have been linked to the development of atherosclerosis and coronary artery disease, two closely related conditions. The study of miRNAs has promoted our understanding of the processes involved in the pathogenesis of atherosclerosis and innovative diagnostic and therapeutic approaches have emerged. In this review, we present the role of miRNAs in the development of atherosclerosis, on coronary artery disease progression and we assess their role as diagnostic biomarkers. Finally we evaluate the therapeutic and preventive opportunities that arise from the study of miRNAs in coronary artery disease and especially in myocardial infarction.

Original publication

DOI

10.1016/j.atherosclerosis.2015.06.037

Type

Journal article

Journal

Atherosclerosis

Publication Date

08/2015

Volume

241

Pages

624 - 633

Keywords

Atherosclerosis, Coronary artery disease, MicroRNAs, Myocardial infarction, Animals, Apoptosis, Atherosclerosis, Biomarkers, Blood Platelets, Cell Movement, Coronary Artery Disease, Disease Progression, Endothelium, Vascular, Gene Expression Regulation, Humans, Lipoproteins, HDL, Lipoproteins, LDL, Mice, MicroRNAs, Monocytes, Muscle, Smooth, Vascular, Myocardial Infarction, Neovascularization, Pathologic, Oligonucleotides, Reperfusion Injury, Stem Cells