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We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)).

Original publication




Journal article


Nat Genet

Publication Date





26 - 28


Adenoma, Cell Line, Tumor, Cells, Cultured, Chromosomes, Human, Pair 15, Colorectal Neoplasms, Genetic Predisposition to Disease, Humans, Jews, Polymorphism, Single Nucleotide