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© Springer-Verlag London 2015. All rights reserved. This patient was diagnosed with assumed type 1 diabetes at the age of 20. She had several years of poor control and gained weight on insulin. Six years post-diagnosis a strong family history was revealed when her brother developed young-onset type 2 diabetes and it was also noted that her mother had diabetes. A C-peptide in the normal range showed that she continued to make endogenous insulin, which would be unusual in type 1 diabetes post-honeymoon period. Molecular genetic testing showed that the patient and her affected family members had maturity-onset diabetes of the young (MODY) due to a hepatocyte nuclear factor 1 alpha (HNF1A) mutation. Following this diagnosis she stopped basal-bolus insulin and her diabetes was managed on 40 mg gliclazide with improved HbA1c.

Original publication

DOI

10.1007/978-1-4471-2789-5_20

Type

Chapter

Book title

Endocrinology and Diabetes: Case Studies, Questions and Commentaries

Publication Date

01/01/2015

Pages

163 - 169