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Interleukin 7 (IL-7) has been demonstrated to be an important regulator of the growth of B and T cell precursors as well as mature T cells, whereas IL-7 has been reported to have no direct myeloproliferative effects. Here we show that IL-7 potently and directly enhances colony stimulating factor-induced myeloid colony formation from Lin-Sca-1+ murine bone marrow progenitor cells, increasing the cloning frequency up to ninefold and cell numbers up to 50-fold, without affecting their ability to differentiate along the myeloid lineages In contrast, IL-7 has no effect on proliferation of committed Lin- myeloid progenitors. Thus, in addition to its established lymphopoietic potential, this study implicates a novel role of IL-7 in early myelopoiesis.

Type

Journal article

Journal

J Exp Med

Publication Date

01/11/1993

Volume

178

Pages

1777 - 1782

Keywords

Animals, Bone Marrow, Bone Marrow Cells, Cell Differentiation, Cell Division, Cells, Cultured, Colony-Forming Units Assay, Colony-Stimulating Factors, Granulocyte Colony-Stimulating Factor, Granulocyte-Macrophage Colony-Stimulating Factor, Hematopoietic Stem Cells, Humans, Interleukin-3, Interleukin-7, Lymphocytes, Macrophage Colony-Stimulating Factor, Mice, Mice, Inbred C57BL, Recombinant Proteins