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The arrangement of the T-cell-receptor and immunoglobulin genes has been analysed in 77 cases of lymphoproliferative disorder. All 6 T-cell leukaemias and 16 of 19 T-cell lymphomas showed rearrangement of the gene coding for the beta chain of the T-cell receptor, associated in all cases with a germline arrangement of the immunoglobulin genes. All 36 B-cell leukaemias and all 16 B-cell lymphomas showed rearrangement of immunoglobulin genes; the T-cell-receptor gene was in the germline configuration in most of these cases but showed a rearranged pattern in 3 cases (2 chronic lymphatic leukaemias and 1 immunoblastic lymphoma). The combined use of T-cell-receptor and immunoglobulin gene probes promises to be a valuable means of identifying and classifying T-cell neoplasms.

Type

Journal article

Journal

Lancet

Publication Date

08/06/1985

Volume

1

Pages

1295 - 1297

Keywords

Autoradiography, B-Lymphocytes, Base Sequence, DNA, DNA Restriction Enzymes, Humans, Immunoglobulins, Leukemia, Lymphoma, Receptors, Antigen, T-Cell, T-Lymphocytes