Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Mechanical forces influence many biological processes via activation of signaling molecules, including the family of Rho GTPases. Within the endothelium, the mechanical force of fluid shear stress regulates the spatiotemporal activation of Rho GTPases, including Rac1. Shear stress-induced Rac1 activation is required for numerous essential biological processes, including changes in permeability, alignment of the actin cytoskeleton, redox signaling, and changes in gene expression. Thus, identifying mechanisms of Rac1 activation and the spatial cues that direct proper localization of the GTPase is essential in order to gain a comprehensive understanding the role of Rac1 in shear stress responses. This commentary will highlight our current understanding of how Rac1 activity is regulated in response to shear stress, as well as the downstream consequences of Rac1 activation.

Original publication

DOI

10.4161/sgtp.28650

Type

Journal article

Journal

Small GTPases

Publication Date

2014

Volume

5

Keywords

Rac1, mechanotransduction, polarity, shear stress, Actin Cytoskeleton, Cell Polarity, Endothelial Cells, Humans, Mechanotransduction, Cellular, Shear Strength, rac GTP-Binding Proteins, rac1 GTP-Binding Protein