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More than 15 years ago, the first generation of genetically engineered mouse (GEM) models of prostate cancer was introduced. These transgenic models utilized prostate-specific promoters to express SV40 oncogenes specifically in prostate epithelium. Since the description of these initial models, there have been a plethora of GEM models of prostate cancer representing various perturbations of oncogenes or tumor suppressors, either alone or in combination. This review describes these GEM models, focusing on their relevance for human prostate cancer and highlighting their strengths and limitations, as well as opportunities for the future.

Original publication




Journal article


Cancer Metastasis Rev

Publication Date





109 - 122


Animals, Disease Models, Animal, Genes, Tumor Suppressor, Humans, Male, Mice, Mice, Transgenic, Neoplasm Metastasis, PTEN Phosphohydrolase, Precancerous Conditions, Prostatic Neoplasms, Proto-Oncogenes, Signal Transduction