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Immune responses against foreign antigens are initiated and controlled by dendritic cells (DCs). Accumulating evidence suggests that autoimmunity, involving T cells directed against self, can also be primed by DCs. We propose that DCs could induce autoimmunity following their differentiation by certain cytokines, or because of intrinsic defects in genes controlling DC function. Both processes result in DCs that behave deviantly.

Type

Journal article

Journal

Immunol Today

Publication Date

05/2000

Volume

21

Pages

214 - 217

Keywords

Animals, Autoimmune Diseases, Cell Differentiation, Dendritic Cells, Humans, Interferon-gamma, Interleukin-6, Mice, Mice, Knockout, Mutation, Rats, Tumor Necrosis Factor-alpha