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Immune responses against foreign antigens are initiated and controlled by dendritic cells (DCs). Accumulating evidence suggests that autoimmunity, involving T cells directed against self, can also be primed by DCs. We propose that DCs could induce autoimmunity following their differentiation by certain cytokines, or because of intrinsic defects in genes controlling DC function. Both processes result in DCs that behave deviantly.


Journal article


Immunol Today

Publication Date





214 - 217


Animals, Autoimmune Diseases, Cell Differentiation, Dendritic Cells, Humans, Interferon-gamma, Interleukin-6, Mice, Mice, Knockout, Mutation, Rats, Tumor Necrosis Factor-alpha